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Engineering  |  FURI

Novel Nanoparticle System to Treat Traumatic Brain Injury

Each year 5.3 million Americans are living with a traumatic brain injury (TBI)-related disability and another 1.4 million individuals suffer from a TBI. The objective of this project was to evaluate a novel nanoparticle system to address the underlying pathology following TBI. Specifically, researchers used RNA seq to analyze global gene expression trends obtained from […]

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Ultrasound Cleavable Polymers for Reversible Vascular Embolization

Embolization therapy uses either particles, metal coils, or balloons to reduce blood supply to a targeted area, starving cancerous tissues. This proposal focuses on creating a polymer that can change from a gelled to a liquid state under high-intensity focused ultrasound (HIFU). With this an embolism that has been mistakenly placed or dislodged can be […]

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Using 1H MRI Reporter S-Gal® to Study Senescent and Quiescent Cells

Senescent and quiescent cells are cells that stop proliferating due to a variety of factors, including stress-induced senescence. Recognizing these cells through MR imaging can help detect dormant  cancer tumors. It has been shown that an enzyme called β-galactosidase (β-gal) is upregulated in senescent and quiescent cells.The combination of S-gal® and ferric ammonium citrate (FAC) […]

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Impact of Electrospun Nanoscaffold Morphology on Cell Fate to Optimize Tissue Regenerative Response

The research objective is to fabricate tunable electrospun nanoscaffolds and analyze their morphology to determine if it is feasible to design an implantable 3D substrate to induce tissue regeneration. Prototypical implantable scaffolds were fabricated from a polymer solution that was propelled via an electric field under set conditions to form electrospun fibers. Scanning electron microscopy […]

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Liquid Embolic Synthesis for Aneurysm Occlusion

The objective of this research is to create an injectable liquid embolic that can degrade as tissue is regenerated for the treatment of cerebral aneurysms. To achieve this, a Michael Addition is formed upon injection of Poly(N-Isopropilacrylamide-co-GAPGLF Acrylate) [Poly(NIPAAm-co-GAPGLF-Ac] and pentaetythritol tetrakis 3-mercaptopriopionate [QT] at 37°C  with a neutral pH, resulting in a gelation. Due […]

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A Combined Optical and Electrical Probe for Electrophysiology

Electrical recordings of individual neurons deep within the brain are key to enhancing understanding of neuronal dynamics. Unfortunately, optical microscopy, which is used to visualize neurons during the recording process, is limited to penetration depths of 500 to 1000 μm due to the optical scattering properties of biological tissues. In this work, researchers use an […]

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