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Engineering  |  FURI

Cloning Antibodies to Understand Neurodegenerative Diseases

Neurodegenerative diseases are still widely misunderstood, but are believed to be caused by the production of β-amyloid peptides (Aβ). Single Chain Fragment Variables (scFv) antibodies can be used to eliminate Aβ, but are difficult to work with. These scFv antibodies can be transformed into Fragment Antigen Binding antibodies (Fab), which are more stable thus easier […]

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Production of NorHA Microspheres for Peptide Tethering

Tissue engineering is an essential part of regenerative medicine. For bone regeneration, scaffolds are used as ways for inducing stem cell proliferation/differentiation, and drug delivery. Current scaffolds are bulky and inefficient. To produce a scaffold that has improved mechanical properties and is less invasive, the scaffold used for this experiment is a hydrogel formed from […]

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Electro Supn Rolled Scaffolds

The research that is being conducted for this project focuses on turning 2-dimensional electro-spun scaffolds into 3-dimensional scaffolds. Four samples at three different time values. The researcher then transformed these 2-dimensional scaffolds into 3-dimensional scaffolds by hand rolling them. The polymer used to create these scaffolds is polycaprolactone (PCL). This is a biodegradable polyester and […]

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Qurry: A Quantum Probabilistic Programming Language

Quantum programming languages are a relatively recent innovation which allows arbitrarily accurate modeling of the physical world. However, these languages are largely still in early development: any lack of true abstraction and are simply proxies to circuit languages and are hardly intuitive. There is reason for this, primarily because the desired semantics of a quantum […]

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MisophoniAPP

The purpose of this project is to introduce MisophoniAPP, a new website for managing misophonia. It will briefly discuss the nature of this chronic syndrome, which is the experience of reacting strongly to certain everyday sounds, or “triggers”. Various forms of Cognitive Behavioral Therapy and the Neural Repatterning Technique are currently used to treat misophonia, […]

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Comparing Protocols for Extracting, Amplifying, and Imaging ApoE ε4 Allele: Preliminary work for understanding Alzheimer’s Disease in asymptomatic individuals

This project aimed to develop a consistent protocol used to effectively image the apolipoprotein E (ApoE) 4 allele, which is a known genetic risk factor for Alzheimer’s Disease (AD). The research team used methods to extract DNA from saliva samples, amplify the DNA using polymerase chain reaction (PCR), and image the results using gel electrophoresis. […]

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Active Thermoregulation for Transtibial Prosthetic Sockets

Transtibial amputation is the most common type of major lower limb amputation.  With approximately 2 million current amputees and 185,000 new cases each year due to vascular diseases (diabetes) in the United States.  The quality of life of an amputee post-surgery relies on the functionality of the prosthetic and the ability for daily use.  Approximately […]

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Improving Treatment of Varicose Veins through Adjustable Compression

Varicose veins affect about 20% of the United States’ population at some point in their lives, causing swelling, blue or purple discoloration, cramping, itching, and burning. The goal of this project is to develop a wrap to fit all sizes that provides gradual and continuous pressure to assist the body’s natural mechanisms in reducing these symptoms. […]

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Characterization of Human Myocardial Tissue Model on a Microfluidic Device

Myocardial infarction is the most prominent cause of heart failure in the U.S. affecting 5.8 million people yearly. Despite the increasing number of affected, there is a lack in understanding as to how the molecular cues involved in a heart attack are created and the specific interactions between the cells that create the formation of […]

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