Heat Transfer Modeling of Solid-State Fermentation Bioreactors to Produce Medicine in Space Habitats

Health

FURI researcher Joy Agus.

Heat Transfer Modeling of Solid-State Fermentation Bioreactors to Produce Medicine in Space Habitats

This project seeks to determine the most optimal design for growing penicillin through solid-state fermentation (SSF) bioreactors. SSF is a promising method used to grow fungi, which can produce antibiotics

Design, Optimization and Control of a Soft Pneumatic Actuator

Soft robotics has seen many exciting applications in human-robot interaction, search and rescue, and even space exploration. Increasing efforts are being made to predict and simulate the behavior of soft

Robot Intent Signaling Using Augmented Reality

Human-robot collaborations are ubiquitous ranging from assembly lines, autonomous vehicles, medical procedures, etc. In such systems, humans and robots work in shared spaces to accomplish a joint task. Successful implementation

Investigating the Strength of Placebo Effects of Transcranial Direct Current Stimulation (tDCS) on Motor Training

Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation thought to initiate cortical excitability. While tDCS has been shown to alter motor learning, the extent to which

Quantification of Shoulder Joint Impedance Based on Various Arm Postures

In this study, we utilize a shoulder exoskeleton robot, which makes use of a 4-bar spherical parallel manipulator (4B-SPM) that has inherently low inertia and as a result can provide

Transcriptomic Assays of Immunometabolic Enhancers

Aging-related diseases are primarily metabolic, leading to long-term inflammation, but in drug discovery, immunometabolism remains difficult to assess and often relies on expensive and low throughput methods like mass spectroscopy

Development of an in vitro Model for the Identification of Volatile Biomarkers Differentiating Streptococcus pneumoniae infection of Human Lung cells

Pneumonia remains one of the leading causes of global mortality affecting 2.49 million people annually due to poor diagnostic measures. One of the bacterial strains contributing to this mortality rate

Analysis of Volatile Organic Compounds Specific to the Treatment of Small Cell Lung Cancer by Cisplatin and Etoposide

Lung cancer is the leading cause of cancer-related deaths globally, claiming 1.59 million lives annually. Numerous efforts have been made to reduce mortality, however, 33% of small cell lung cancer

Passive Exoskeleton for Sit-To-Stand and Stand-To-Sit Transfer

Imagine the possibility of a cure for one of the most prevalent problems associated with aging. Numerous individuals experience difficulty getting out of bed, sitting, or performing normal tasks due

Movement and Quantification of E. coli in a Managed Aquifer Recharge Site

This study quantifies Escherichia coli (E. coli) in water sources in a managed aquifer recharge site and characterizes its movement through clay loam. E. coli is a typical fecal indicator bacteria in wastewater, and

An Integrative Personalized Wearable Indirect Calorimeter

A personal indirect calorimeter allows everyone to assess energy expenditure (metabolic rate or metabolism (kcal/day)) through breath analysis, thus enabling accurate determination of a person’s total caloric intake needs for

Impact of Human Body Shape on Convective Heat Transfer Coefficient

People are exposed to a variety of thermal environments every day. Understanding and predicting an individual’s heat stress and strain potential in various thermal environments is crucial. Previous human thermal

Testing the Effect of Water Temperature and Disinfectants on Biofilm Formation by Different Bacteria in Different Pipe Materials

With the increase in world population, waterborne diseases are also increasing. Drinking water distribution systems (DWDS) biofilms can harbor pathogens, and opportunistic pathogens such as Legionella spp. and E. coli

Correlations Between Deep Brain Stimulation of the Subthalamic Nucleus, Blood Flow, Oxygenation, and Neural Activity

Deep brain stimulation (DBS) is a method of neuromodulation in which implanted electrodes produce electrical impulses for the treatment of neurological disorders like Parkinson’s disease (PD), epilepsy, and dystonia. DBS

RNA’s Higher Order Structure and Its Effect on Stability and Function for Medical Application

Research in this study investigates whether the structural motif Degradation Tuning Ribonucleic Acid (dt-RNA) enhances the function of aptamers for COVID-19 testing kits and increases the stability of mi-RNA. This

A Causal Approach to Predicting Medical Conditions in Machine Learning

A causal approach to machine learning is currently being investigated to better explain, understand, and apply machine learning models. The focus of this study is to use this causal approach

Optimization of PEG-Polyurethane Polymers for Biomedical Applications

Poly (ethylene glycol) (PEG)-Polyurethane polymers are currently being used in tissue regeneration scaffolds, heart valves, and wound healing applications. Targeting specific PEG-Polyurethane properties can address the clinical needs mentioned above.

Open-Source Cost-Effective 3D-Printed Anthropomorphic Neuroprosthetics

An anthropomorphic neuroprosthetics arm is a bionic arm that will help people replicate much of the function of a native human arm. Artificial limbs are essential to improve the quality

Fine-Tuning Pre-Trained Models to Determine Model Superiority for Enhanced Medical Image Diagnosis

The biggest challenge in computer-aided diagnosis remains the slow nature of the data annotation process. No large-scale evaluation has performed a comparison on the many pre-trained models in existence. In

Movement and Quantification of E. coli in a Managed Aquifer Recharge Site

This study quantifies Escherichia coli in water sources in a managed aquifer recharge site and characterizes E. coli movement through clay loam. E. coli is a fecal indicator bacteria found

Assaying the Effect of Knock-Down of Ubiquitin-Specific Proteases in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare but aggressive cancer that resides in the pleural space surrounding the lungs. The median survival rate for MPM remains poor even with existing

Chemotherapeutic Drug-Conjugated Microbead Technology for Selective Binding with Methylated and Unmethylated Small DNA in the Application of Disease Detection and Biomanufacturing

In a previous study, it was discovered that aminoglycoside-derived cationic polymer microbeads (also called Amikabeads) have significant binding affinity toward negatively charged plasmid DNA due to coulombic interactions. The purpose

Analyzing Parameters Optimum for a Highly Sensitive Analyte Sensor in a Point of Care Medical Device

Existing analyte measurement techniques are error-prone, time-consuming, and expensive. Hence, a handheld medical device capable of accurately measuring the amount of analyte (as low as 10 micromolar) in the blood

Using Kinematic Analysis to Identify Loci of Improvement During Functional Motor Skill Training

Improvement in the efficiency, accuracy, and timeliness of a functional motor task likely correlates to an improvement in related motions of daily life (Winstein and Stewart, 2006). The functional motor

Using Batched Rays to Enable Higher Resolution Reconstruction of Computed Tomography Images

In our work, we tried to enable the reconstruction of high-resolution computed tomography (CT) images using implicit neural networks which usually require access to large amounts of graphics processing unit

Variable Stiffness as Control Scheme for Enhancing Active Ankle Foot Orthosis

During walking, the human ankle accommodates for surface irregularities during the stance phase by changing its mechanical impedance to a stiffness dominant joint. To prevent discomfort to an ankle-foot orthosis

Viability of Magnets and Robotics on Advanced Surgeries

This project aims to utilize magnets and a robot capable of great precision in order to determine new techniques that will improve the efficacy of minimally invasive surgeries. Through sensory

Effect of Bimodal Sensory Integration on Reactionary Impulsivity

This research investigates the utilization of neural summation resulting from multisensory integration during action inhibition. Combining the race model inequality, which implies neural summation from bimodal stimuli, with the stop

Lesion Detection using Three-Dimensional CBCT Image Segmentation using Deep Learning

The goal of this project is to implement an efficient and accurate 3D semantic segmentation on Cone-Beam Computed Tomography (CBCT) dental imaging for accurate lesion detection using a 3D U-Net

Development of Biomimetic Nanoparticles for Highly Efficient CRISPR Delivery

Recent advances in genome engineering, namely Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 gene editing, have revolutionized biomedical research and hold promise for treating genetic disorders. However, inefficient delivery and

Characterizing Postural Stability During Smartphone Use on Dynamically Unstable Environments

Past studies have shown negative effects of smartphone usage on standing postural balance, but mostly focused on traditional tasks like calling or texting. As part of modern life, smartphones are

Using 3D Printing to Develop a Placenta-on-a-Chip Model

Placental trophoblasts support fetal growth and survival, but the behavior of these cells is challenging to study in vivo and in two-dimensional culture systems. In this project, we investigate the

Detecting and Analyzing Physical Movements Using Machine Learning

The hardware detects the movement of the user and utilizes a neural network to recognize correct movement patterns. Previous research used data imported from infrared scanners in order to build

Characterization of Adhesive Peptide Binding Efficacy in SPAAC and Michael-Type Addition PEG Hydrogels to Support Encapsulated Pancreatic Islet Cell Viability

A promising treatment for Type 1 diabetes is encapsulation of pancreatic islet cells in hydrogels, which may prevent transplant issues, like immune rejection. These hydrogels can be modified to promote

Biomedical engineering graduate student Emmanuella Tagoe works with Professor Marco Santello.

Investigating How Training Improves Dexterous Finger Force Control

Many activities of daily living like buttoning shirts or threading a needle require dexterous control of appropriate forces (or movement) of individual fingers. However, intending to move one finger is

Filtering MRI Images to Improve Pharmacokinetic Modeling of GdDO3NI in Brain Tumors

Pharmacokinetics involves the study of the movement of exogenous chemicals such as drugs and imaging agents through the body. Modeling the passage of a hypoxia targeting imaging agent using Magnetic

Graph-Guided Assembly and Typing of the HLA Alleles from RNA-seq Data

Human Leukocyte Antigens (HLA) are encoded by a polymorphic set of genes where even a single base change can impact the function of the body’s immune response to foreign antigens

Fatigue Analysis of Additively Manufactured Ti-6Al-4V for Biomedical Applications: Permanent Bone Screws

Additively manufactured (AM) materials are being used increasingly in many industries, specifically the health sector. AM materials are highly advantageous as they can be quickly produced and are custom-created to

Modeling Deviation in Bending Direction of a Soft Arm Manipulator Using Regressive Neural Networks

The compliant nature of a soft robot’s material and design offers certain challenges when it comes to modeling and control. The lack of rigid structures allows the system to bend

3D-Printed Electroactive Hydrogel-Based Microgripper for Biomedical Applications

Hydrogels are 3D interconnected systems of polymer chains that can soak and store liquid, this characteristic makes them supple and soft. Electroactive hydrogel-based microgrippers respond to stimuli and demonstrate the

Christabel Wireko Arthur

Synthesis of a Janus Particle with Gold Nanoparticles and Vesicle-like Mesoporous Silica

A Janus Particle is a special type of nano or microparticle whose surface has two or more distinct physical and chemical properties. The aim of this research is to explore

Passive Exoskeleton for Sit-To-Stand and Stand-To-Sit Transfer

Imagine the possibility of a cure for one of the most prevalent problems associated with aging. Numerous individuals experience difficulty getting out of bed, sitting, or performing normal tasks due

Investigation of Inflammation Behavior of Aminoglycoside-Based Polymer Library

We will investigate the inflammation response an in vivo sample has upon varying polymers. This will include, but will not be limited to, polymers such as: Neomycin-GDE Polymer (NG), Paromomycin-GDE

Gait and Balance Comparison Between Young and Elderly Adults: Minimizing Fall Risk

IMUs (Inertial Measurement Units) are commonly used to monitor patients who are prone to falls. With the help of these devices, the research team will simultaneously collect data on both

Transfecting B35 Neuroblastoma Cells with Optogenetic Protein for Micropipette Excitation

Subthreshold events are essential because they provide the foundation for neuroplasticity, adjusting the likelihood of reaching an action potential threshold. These events may be visualized on a microscope platform with

Characterization of Trophoblast Derived Exosomes to Engineer an Immunomodulatory Macroencapsulation Device for Cell Therapies

Trophoblasts are cells that populate the human placenta and release extracellular vesicles called exosomes, involved in cell-to-cell communication. Trophoblasts are believed to be involved in site-specific immunomodulation and their exosomes

Viability and Metabolic Function of INS-1E Cells in Synthetic PEG Hydrogels Suitable to Injection Molding Biofabrication

Pancreatic islet encapsulation has the potential to reverse Type 1 diabetes by protecting transplanted beta cells from immune-cell destruction while allowing passive diffusion of nutrients through a synthetic non-degradable hydrogel

Expanding Injection Molding Biofabrication to Generate Complex Three-Dimensional Cell Encapsulation Geometries

Encapsulation is a promising technology to deliver cell-based therapies to patients safely and with reduced need for immunosuppression. Macroencapsulation devices are advantageous due to their ease of retrieval, and thus

Assistive Technology for the Visually Impaired for Navigating Cluttered Environments

Several assistive devices and products have been made available in the market in the past few years for the visually impaired. These devices provide feedback to the user through senses

Trophoblast-On-Chip Model

The maternal-fetal interface is challenging to investigate in in vivo models due to species-specific differences in placental development and ethics evaluating placental development in humans during gestation. The research team

Development of an in vitro Model for the Identification of Volatile Biomarkers of Pneumonia

Pneumonia remains one of the leading causes of global mortality affecting 2.49 million people annually due to poor diagnostic measures. In recent years, volatile organic compounds (VOCs) have emerged as

Boosting TCR and Epitope Binding Affinity via Supervised Contrastive Loss

In this paper, the research team investigates using Supervised Contrastive Loss (SCL) instead of Cross Entropy Loss (CEL) as the loss optimization function in existing machine learning models that are

An Inexpensive and Simple Optical Sensor System for Lab-Based Rapid Testing

With the uncertainty and high-risk nature of infectious diseases, rapid testing is needed to protect the community from an epidemic. A new antigen testing method using Gold Nano-Particles (AuNP) is

Quantification of Antibiotic Resistance Genes in a Managed Aquifer Recharge System

Managed Aquifer Recharge (MAR) offers sustainable replenishment of groundwater resources using treated wastewater effluent. Antibiotic Resistance Genes (ARGs) may withstand wastewater treatment, conferring the ability of bacteria to resist antibacterial

Synthesis and Characterization of PEG-Polyurethane for Biomedical Applications

Poly (ethylene glycol) (PEG)-Polyurethane polymers are currently being investigated for biomedical applications such as tissue regeneration, heart applications, and wound healing. Improving the overall properties of PEG-Polyurethane can address a

Assessing Visuospatial Function Using the Shepard-Metzler Mental Rotation Task in an Online 3D Mode

Over the years, the Shepard-Metzler Mental Rotation Task (MRT) has proven to be a reliable tool for assessing people’s visuospatial ability. This study will compare the online 3D MRT to

Effectiveness of Waist Vibrotactile Feedback for Improving Posture Balance

This research verifies the effectiveness of improving posture stability through vibrotactile biofeedback under oscillatory circumstances, which is simulated by the force platform. Subjects were asked to perform a quiet stance

Effect of Fused Deposition Modeling Printing Parameters on Mechanical and Thermal Behavior of PLA/Nanodiamond Composite

Poly Lactic Acid (PLA), a thermoplastic polymer is well known for its biocompatibility, making it ideal for the manufacturing of biomedical devices. However, the current applications of PLA are limited

Analysis of Small Cell Lung Cancer-Specific Volatile Organic Compounds in Hypoxic Conditions

Lung cancer is the leading cause of cancer-related deaths globally, where 84% of cases are diagnosed late when treatments are no longer effective. Limitations in current diagnostic tools have resulted

Flexible Fractal-Inspired Metamaterial for Head Imaging at 3 Tesla MRI

The noninvasiveness and increased tissue contrast of magnetic resonance imaging (MRI) make it an advantageous diagnostic tool relative to its contemporaries, such as CT and PET scans. In high-field MRI,

Effect of Bimodal Sensory Integration on Reactionary Impulsivity

This research investigates the utilization of neural summation resulting from multisensory integration during action inhibition. Combining the race model inequality, which implies neural summation from bimodal stimuli, with the stop

Curved Implementation in a Variable Impedance Controller for a Robotic Ankle Joint

The research conducted in this project seeks to expand the applicability of a recently introduced and experimentally verified variable impedance controller which dynamically modulates both damping and stiffness to inject

Combined Effect of Variable Stiffness and Damping Controller to Correct and Augment Ankle Motion

Human walking is associated with exertion that results in muscle fatigue. Fatigue is an important parameter that determines the deviation of abnormal gait. But accurate forces to an abnormal gait

Nucleic Acid Delivery from 3D-Printed Scaffolds

3D printing/bioprinting and gene activated matrix are promising techniques to fabricate scaffolds with well-controlled and patient-specific structures and gene delivery for tissue engineering. In this study, we developed derivatives of

Margarito Hernandez Fuentes

Assaying the Effect of Knock-Down of Ubiquitin-Specific Proteases in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare but aggressive cancer that resides in the pleural space surrounding the lungs. While treatment options are available, the median survival rate for MPM

Extended Kalman Filter Based Sensor Fusion for State Estimation of a Soft Robot Arm

Soft robots could be used directly with humans without the danger that is inherently associated with rigid robots. Currently, one major issue with soft robots is the lack of reliable

Designing an Affordable Torsional Spring for a Rotary Series Elastic Actuator

Rotary Series Elastic Actuators are commonly used in rehabilitation exoskeletons due to their inherent compliance creating a level of safety and comfort. Designing and manufacturing torsional springs for this purpose

Chemotherapeutic Drug-Conjugated Microbead Technology for Selective Binding with Methylated and Unmethylated Small DNA in the Application of Disease Detection and Biomanufacturing

In a previous study, it was discovered that aminoglycoside-derived cationic polymer microbeads (called Amikabeads) have significant binding affinity towards negatively charged plasmid DNA due to coulombic interactions. The purpose of

Assessing Spectrophotometry for Regenerative Medicine Biomanufacturing Biomonitoring

Regenerative medicine utilizes living cells to replace or repair damaged or diseased tissue. Living cells are constantly changing and reacting to their environment, therefore the manufacturing process to get those

Development of CRISPR Interference Constructs to Modulate the Phenotypic Switch of Vascular Smooth Muscle Cells

Previous studies highlight the critical role that upregulation of Kruppel-like factor 4 (KLF4) plays in promoting the pathological phenotype of vascular smooth muscle cells (VSMCs). This FURI project adopted a

Light-Activated Sealants for Internal Organ Repair and Healing

Current techniques for internal organ sealing and repair can cause additional trauma, may lack adhesive properties, or cause an inflammatory response. The focus of this study is to develop a

Directly Relating Magnetic Resonance Electrical Impedance Tomography (MREIT) Data to Membrane Conductivity during Neural Activity In Vitro

This research is concerned with analyzing a new type of magnetic resonance imaging (MRI) called magnetic resonance electrical impedance tomography (MREIT) which may be able to be used to more

Graph-Guided-Assembly and Typing of the HLA Alleles from RNA-seq Data

The HLA, Human Leukocyte Antigens, are encoded by a polymorphic set of genes where even a single base change can impact the function of the body’s immune response to foreign

Harnessing Zika Virus to Access the Neuroimmune System

Neuroinflammation has been implicated in nearly every neurodevelopmental, and degenerative disease, yet the capability to manipulate neuroimmune cell types remain limited. Microglia, a neuroimmune cell type, have developed a resistance to

Immunomodulatory Exosome Loaded Synthetic Hydrogels for Cell Encapsulation

Pregnancy is a natural phenomenon where tissue types of different antigen signatures co-exist without eliciting an immune response from the host. Immunomodulation occurs in a site-specific manner at this interface

Engineering of Light-Based Promoters with PACE and eVOLVER Continuous Culture Hardware

Phage-assisted continuous evolution (PACE) is a revolutionary new method to rapidly engineer new genes and proteins, but the method requires extensive automation and expensive chemical inducers for precise control of

Towards the Development of a Longitudinal Rehabilitation Study for Postural Stability in Children with Cerebral Palsy

Studying how children with cerebral palsy balance under certain circulstances will inform future rehabilitation methods.

Drug Delivery in the Brain Using Iontophoresis through Microscale Pipettes to Modulate Single Cell Function

The need for controlled drug administration has become increasingly critical for the treatment of neurological diseases. Iontophoresis, a technique that uses current to move molecules, has been explored. The goals

Development of a Genome Editing Tool to Target Modulation Genes In Vascular Smooth Muscle Tissue

Vascular stenosis, a pathology characterized by plaque buildup in arteries, is associated with a biological hallmark: the phenotypic switch from a quiescent contractile to a proliferative synthetic phase of vascular

Engineering of Light-Based Promoters with PACE and eVOLVER Continuous Culture Hardware

Phage assisted continuous evolution (PACE) is a revolutionary new method to rapidly engineer new genes and proteins, but the method requires extensive automation for precise control of gene expression. The

Light-Activated Sealants for Internal Organ Repair and Healing

Current techniques for internal organ sealing and repair can cause additional trauma, may lack adhesive properties, or cause an inflammatory response. The focus of this study is to develop a

High-Speed 3D Printing of Electroactive Hydrogel for Soft Robotics

A new method of additive manufacturing called Projection Micro Stereolithography (PμSL) has made fabricating micro-scale designs more convenient, and is capable of printing high-resolution electroactive hydrogel parts from photosensitive liquid

Lily Baye-Wallace demonstrates a hip exosuit

A Soft Robotic Hip Exosuit (SR-HExo) to Enable Entrainment during Human Locomotion

Over 7 million American stroke survivors require gait rehabilitation due to initial or persistent mobility deficits. Expansion of the “basin of entrainment” is a rehabilitative practice that improves gait uniformity

Simulation-Guided Preparation of 3D In Vitro Models with Predictable Oxygen Distribution

Tissue oxygenation is an emerging area of study as scientific literature suggests hypoxia playing a key role in the progression of various diseases including cancer, stroke, and traumatic injuries. This

CK2 Phosphorylation of Tom22: Conserved or Convergently Evolved?

The translocase of the outer mitochondrial membrane (TOM) complex is the gateway into mitochondria. Phosphorylation of the receptor, Tom22, by the kinases CK1 and CK2 in both animals and fungi

Designing an Affordable Torsional Spring for a Rotary Series Elastic Actuator

Rotary Series Elastic Actuators are commonly used in rehabilitation exoskeletons due to their inherent compliance creating a level of safety and comfort. Designing and manufacturing torsional springs for this purpose

Synthesis and Characterization of Immunomodulatory Microparticles for the Induction of Tolerance Against Dietary Antigens

Given that metabolism can control immune cell function1 and that the presentation of an antigen by anti-inflammatory dendritic cells can lead to the expansion of anti-inflammatory immune responses2, this project

A Comparison of CRISPR/Cas-Derived Genome Editing Methods for hPSCs

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 systems are a vital gene-editing tool for generating in vitro disease models. Since its debut, many CRISPR-derived editing techniques have been created to increase

Monitoring Upright Posture in Individuals with Parkinson’s Disease: Foundations for a System to Provide Real-Time Feedback

Stooped posture is one of the main characteristic features in Parkinson’s Disease (PD). While the severity of stooped posture (SP) varies from person to person, research has shown that the

Cell Viability of Insulin-Producing Cells After Injection Into Complex Hydrogel Shapes in Macroencapsulation Device

This project investigates an injection molding device for complex hydrogel geometries to macroencapsulate donor islet cells. The injection process requires that cells be mixed with hydrogel and injected into the

Designing Personalized Assistive Technology for Student with Cerebral Palsy

One of the symptoms of Cerebral Palsy (CP) is the lack of spatial awareness due to the inability to respond well to visual cues. This project seeks to augment visual

Using Machine Learning to Quantify Colorimetric Assays from Cell Phone Photos

Finding a method to objectively quantify results of colorimetric assays without special equipment is important to increasing the accessibility and portability of point-of-care testing. Point-of-care testing is inexpensive, has quick

Factors that Influence Ankle Stiffness During the Stance Phase of Walking

Understanding human joint mechanical impedance — a measurement reflecting stiffness, damping, and inertia — is a potentially useful metric for diagnostic purposes that can also aid in the design of

Simulation-Guided Preparation of 3D In Vitro Models with Predictable Oxygen Distribution

Tissue oxygenation is an emerging area of study as knowledge suggests that hypoxia plays a key role in the progression of various diseases including cancer, stroke, and traumatic injuries. This

Development of a Genome Engineering Approach for the Modulation of Vascular Phenotypes

Atherosclerosis is the leading cause of death for cardiovascular diseases and the phenotypic switch of vascular smooth muscle cells (VSMCs) mediated by the upregulation of KLF4 contributes to the progression

Investigation of Reactive Oxidative Stress Using a Uniaxial Stretch Model to Simulate Physiological Micromotion Induced Cyclic Strain on Brain

Physiological micromotion, such as breathing and vascular pulsations, has a significant impact on the reliability of implants used in neuromodulation therapies. Micromotion-induced stresses and strain are hypothesized to impact neuronal

Schlieren Optics and Photoacoustic Imaging Development

The purpose of the research is to shorten diagnostic times by developing a new real-time Photoacoustic Microscopy imaging technique. Photoacoustic microscopy can target naturally occurring absorbers as well as exogenous

panCanSYGNAL

A web application has been developed to provide data and statistics for comprehensive gene regulatory network of the deadly cancer malignant pleural mesothelioma (MPM). The web application was enhanced to

Electrocorticography Array for Simultaneous Measurement of Local Field Potentials and Tissue Oxygenation

Nervous tissue is known to be extremely vulnerable to discontinuities of oxygen and energy substrates. The brain must have a constant supply of energy to prevent abnormal behavior because the

Dean Spyres and Mayo Clinic staff.

3D Printed Indirect Ophthalmoscope Accessory for Mobile Device

Ophthalmoscopes are integral to diagnosing a variety of eye conditions, however, they often come at a hefty cost and are not generally portable making access limited. With the increase in

How Does Simulated Physiological, Cyclic Stretch Affect Oxygen Demand at Neural Interfaces?

Neuromodulation devices are a very important therapeutic tool for many neurological disorders such as in deep brain stimulation for Parkinson’s disease. It is important to know how biological and mechanical

Modeling Mechanical Properties of Fibrous, Polymer Scaffolds as a Function of Fiber Alignment

Musculoskeletal tissues, ranging from tendon to cartilage to bone, contains an extracellular matrix with unique fiber alignments and mechanical properties. Designing tissue engineered scaffolds that mimic these tissue properties is

Modulating Gait Symmetric Adaptation via Split-Belt Treadmill Distortion and Explicit Visual Feedback Distortion and Evaluating the Aftereffects of Adapted Step Length Symmetry

Following neurological disease or injury, such as stroke, it is common for patients to lose functionality and coordination of their lower limbs. Rehabilitation techniques, such as gait training, are widely

Transfecting B35 Neuroblastoma Cells with Near Infrared Protein for Photoacoustic Detection

Viewing biological processes at depth in tissues is essential for the study and diagnosis of neurodegenerative and neurological diseases. Despite recent advancements, current optical techniques are restricted to an imaging

Photoacoustic Imaging with Schlieren Optics to Provide Real-Time Imaging

Wide-field photoacoustic microscopy (PAM) images are challenging to display in real-time because these images are reconstructed from multiple one-dimensional scans. This delay limits both research and clinical applications for PAM.

Building a Regulatory Network to Explore the Immune Landscape of Mesothelioma

Mesothelioma is a rare and deadly cancer that typically consists of tumors in the pleural cavity of the lungs. This research showcases a regulatory network using the previously built SYGNAL

Control of Tissue Homeostasis, Tumorigenesis, and Degeneration by Coupled Bidirectional Bistable Switches

The Hippo signaling pathway plays a key role in determining organ size and maintaining tissue homeostasis through regulation of apoptosis and cell proliferation. Disrupting the balance between these biological processes

Testing Method of Soft Actuator

Elderly around the world have been diagnosed with mobility impairment due to various diseases that cause weak joints and muscles. The Kaiteki Project proposes a wearable hybrid robotic system that

Statistical Modeling of Drug Release from Spherical Surface-Degrading Particle Batch

Drug-eluting microparticles have been identified as a method of drug delivery capable of delivering controlled local treatment over time. To address the need of adhering to strict drug delivery standards,

Autonomous Online PID Tuning Algorithm and Implementation on a Knee Exoskeleton

Proportional-Integral-Derivative controllers (PID) are widely used in rehabilitation robotics and the ability to tune the controllers in the presence of unmodelled nonlinearities is essential to the performance of the controller.

RF (Radio Frequency) Micro-Coil Design for Small Animal MRI

The research question to be answered by this project would be whether the developed RF (Resonance Frequency) coil could generate the frequency of 297 MHz that is required to operate

Maintaining Long Term Adherence to BRIDGES Protocols

mHealth Apps, also known as Mobile Health Applications, refers to the “use of mobile and wireless technologies to support the achievement of health objectives,” according to the World Health Organization.

The Effect of Sleep Deprivation on the Startle Response

The reticulospinal system of the brain is responsible for learning motor skills. As humans age, the quality and quantity of sleep continually decreases leading to memory and learning deficits. In

Development of a Wearable Hybrid-PassiveAnkle-Foot Orthosis for Rehabilitative and Assistive Applications

During normal walking, there is significant power required in the ankle to propel the body forward near toe-off. In the case of the elderly or those with neuromuscular disorders, this

Propagation of Interictal Spikes in Epilepsy

Interictal spikes are typically regarded as a sign of epilepsy, although their precise role in epilepsy remains vague. This study explores the spatiotemporal dynamics of sequences of interictal spikes in

Performing Phenotypical Studies For An Adaptable Multi-Modality pH-Sensitive Nanoprobe for Real-Time Monitoring of Engineered Cells and Tissues

A versatile technology for the assessment of cell and tissue viability in different culture systems remains a concern in the biomanufacturing industry. Through this project, the research team studied the

Assessing Technology Best Suited for Regenerative Medicine Biomanufacturing Biomonitoring

Regenerative medicine utilizes living cells to replace or repair damaged or diseased tissue, but the manufacturing process to get those cells is unlike typical manufacturing. Living cells are constantly changing

Detection of Irradiated Foods Packed in Plastic and Glass Using Electron Paramagnetic Resonance (EPR) Spectrometry

Food irradiation is performed to improve the safety of foods by reducing pathogenic microorganisms. Many foodstuffs are irradiated to preserve and prolong their life span. Though a standard symbol exists,

Alexis Hocken

Characterizing Nanocomposites for Customizable Cartilage Replacements

The properties and characteristics of photocurable nanocomposites can be tailored to mimic those of various tissues and/or cartilage, allowing the bio-inspired synthetic material to replace them. The long-term goal of

The Use of a Virtual Cane for Improving Standing Postural Stability

This study introduces a virtual cane (VC) device for improving standing balance. Unlike typical canes, VC does not provide any physical support but haptic feedback to help users adjust their

Study Examining Human Postural Stability with Perturbations Applied Utilizing Dual-Axis Robotic Platform

This study investigated the impacts of 2-dimensional oscillatory perturbations on human standing balance. A dual-axis robotic platform was utilized to apply oscillatory perturbations and evaluate the subject’s postural stability during

Model-on-Demand (MoD) Estimation for Behavioral Intervention Optimization

This project explores the use of Model-on-Demand (MoD) estimation to model noisy, nonlinear time series data. MoD estimation has been examined for two applications: (1) a continuously-stirred tank reactor and

Directly Relating Magnetic Resonance Electrical Impedance Tomography (MREIT) Data to Membrane Conductivity during Neural Activity In Vitro

This research is concerned with analyzing a new type of magnetic resonance imaging (MRI) called magnetic resonance electrical impedance tomography (MREIT) in an effort to be able to use it

Pandemic Agent-Based Modeling in a Learning Environment

The objective of this project is to design and model transmission dynamics of COVID-19 in a closed learning environment for the purpose of analyzing and comparing methods for alternative classroom

Lower Motor Neuron Degeneration Following Traumatic Brain Injury

This project aims to determine the extent that traumatic brain injury (TBI) affects lower motor neuron (LMN) degeneration and neurodegeneration within the cervical region of the spinal cord post TBI.

Size-Tunable Polymeric Nanoparticles for Drug Delivery after Traumatic Brain Injury

Five million people in the United States live with disabilities caused by traumatic brain injury (TBI). TBI can break down the blood-brain barrier (BBB), the membrane that regulates what enters

Metabolite-based Cancer Vaccine to Modify Immunometabolism and Prevent Melanoma Growth in Aging Mice

Cancer vaccines generate robust antigen-specific anti-tumor responses by adjuvant-mediated induction of high energy-consumption state in immune cells. Unfortunately, this elevated and sustained energy immunometabolism mediated activation of immune cells is

Microneedles for Basal Cell Carcinoma

This project proposes a new method in delivering vismodegib, a chemotherapy drug that is taken orally for the treatment of basal cell carcinoma (BCC). BCC therapeutics in chemotherapy tend to

Vibro-Thermal Device for Socio-Emotional Communication through Pattern Generation

Touch plays an essential social role in fostering and maintaining emotional communication in human relationships, which has changed due to the current pandemic. The research team proposes to create a

Lauren Lossner

Interictal Spike Depolarization in the Neocortex: Relationship to Action Potential Inactivation

Evaluated how local voltage changes due to interictal spikes impact action potential firing using intracellular recordings and the Hodgkin-Huxley model. The Hodgkin-Huxley model showed inactivated action potentials being generated by

Testing Method of Soft Actuator

Elderly around the world have been diagnosed with mobility impairment due to various diseases that cause weak joints and muscles. The Kaiteki Project proposes a wearable hybrid robotic system that

Modeling Mechanical Properties of Fibrous, Polymer Scaffolds as a Function of Fiber Alignment

Musculoskeletal tissues, ranging from tendon to cartilage to bone, contains an extracellular matrix with unique fiber alignments and mechanical properties. Designing tissue engineered scaffolds that mimic these tissue properties is

Machine Learning Model for Classifying Colorimetric Assays

The focus of this study is to design a machine learning model that can classify alcohol test strips as positive or negative from cell phone photos taken under non-standard conditions.

Synthesis of Covalent Organic Frameworks (COFs) for the Purpose of Encapsulating and Releasing Tuberculosis Drugs

Drug delivery methods can be demanding on the patient and require them to administer drugs on their own. This is demanding and tedious on the individual. Covalent Organic Frameworks (COFs)

Ligand-functionalized Microbeads for Preferential Binding of Methylated and Unmethylated DNA

In the previous study polymer microbeads (namely Amikabeads) were developed which contain a monomer (Amikacin Hydrate) and a cross linker (PolyEthylene Glycol Diglycidyl Ether or PEGDE). This research is looking

panCanSYGNAL

A web application has been developed to provide data and statistics for comprehensive gene regulatory network the deadly cancer malignant pleural mesothelioma (MPM). The web application was enhanced to include

Pet Diagnostic Health Harness

The objective of this project is to design a product with the capability of gathering health diagnostics from a pet and relaying that information to its owners. The goal is

A Continuation of the Exploration of the Connection Between Particulate Composition and Mean Granule Size

Pharmaceuticals are an integral part of many peoples’ lives and while billions of dollars are poured into research and development little is known about the effect of process variables on

Constructing a Chlorine Sensor For Use In Developing Nations

Chlorination is the most common approach to disinfecting water, however, it requires a precise concentration level to work effectively. Determining how much chlorine to add is often difficult for these

Kristin Huber

Assessment of Injury Induced Blood Brain Barrier Disruption and Necroptosis via Development of Rapid Data Analysis Pipeline

Previous modes of image analysis were determined to be unfit for efficient usage in laboratory analysis tasks. Improvements were made upon the Java application created during Summer 2020 FURI, including

RF (Radio Frequency) Micro-Coil Design for Small Animal MRI

The research question to be answered by this project would be whether the developed RF (radio frequency) coil could generate the frequency of 297 MHz that is required to operate

The Use of Spatial Audio as a Navigation Aid for the Visually Impaired

Spatialized audio gives the user the perception that there is sound coming from a source in a 3D environment. Meteor Studio has developed an algorithm that enables the spatialization of

A Comparison of CRISPR/Cas-Derived Genome Editing Methods for hPSCs

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 systems are a vital gene editing tool for generating in vitro disease models. Since its debut, many CRISPR-derived editing techniques have been created

Testing Method of Soft Actuator

Elderly around the world have been diagnosed with mobility impairment due to various diseases that cause weak joints and muscles. The Kaiteki Project proposes a wearable hybrid robotic system that

Incorporating Fluorescent Nanoprobe Emulsions in Hydrogels for Non-invasive Oxygen Measurement

The long-term goal of this research is to transplant encapsulated beta cells into a diabetic recipient and eliminate insulin injections. Beta cells succumb easily to hypoxic environments. To test oxygen

Towards Automated Identification of Cancer Immunotherapy Targets: Prediction of Binding Affinity of T Cell Receptor and Antigens Using Graph-Guided Deep Neural Network

Cancer can be treated through immunotherapy, a personalized treatment to train a person’s own body to create an immune response towards cancer cells. The problem arises in understanding when a

Photoacoustic Microscopy with Schlieren Optics to Provide Real-Time Imaging

Wide-field photoacoustic microscopy (PAM) images are challenging to display in real-time because these systems only gather one dimensional depth scans per laser pulse. Reconstructing these images is time consuming since

Characterization and Modeling of Ankle Impedance During the Stance Phase of Walking

Understanding human joint mechanical impedance – a measurement reflecting stiffness, damping, and inertia – is a potentially useful metric for diagnostic purposes that can also aid in the design of

Examining the Anti-Proliferative Properties of DUB Inhibitors in Primary Mesothelioma Cells

Mesothelioma is a rare and deadly cancer that typically consists of tumors in the pleural cavity of the lungs. A CRISPR/Cas-9 knockout screen was performed to study the effect of

Study on Human Postural Stability During Upright Standing Using Novel Two-Axis Robotic Platform

Quantifying human standing stability under 2-dimensional (2D) dynamically unstable environments is critical since those environments are related to falling and its consequences. This study investigates the standing stability under 2D

Deuterium Metabolic Imaging of Physiological Levels of Glucose

The aim of this project is to identify literature in which supports the idea that Deuterium Metabolic Imaging (DMI) can be applied to detect normal physiological levels of glucose. There

Creation of a Computational File for Calculating Drug Release from Degradable Spherical Gel Batch

Drug-eluting particles have been identified as a method of drug delivery capable of delivering steady local treatment over time. To address the need of adhering to strict drug delivery standards,

Investigation of a polyether urethane-based polymer for promoting bone tissue healing

Interest in the field of tissue engineering is rapidly increasing due to its role in providing a platform for regenerative medicine and tissue repair solutions. In particular, there is a

Development of the SmartPad System for Energy Expenditure Detection

Energy Expenditure (EE) is the energy organisms utilize to carry out their cognitive and physical actions. A mismatch between EE, energy storage, or energy intake can lead to a variety

The Development of Geometries for a Passive Check Valve in Patients with Hydrocephalus

Hydrocephalus (HCP) is a medical condition where an excess amount of cerebrospinal fluid (CSF) accumulates within the ventricles of the brain. As CSF accumulates, it exerts pressure on the brain.

Investigating PEG-Polyurethane for Biomedical Applications

PEG-Polyurethane is being used for biomedical applications such as in catheters, heart valves and in tissue regeneration including bone. Improvements in the polymer’s properties are needed to specifically facilitate different

Characterizing Cellular Response to Topological Features on a Nanoscale Utilizing Monolithic Quartz Contact Guidance Chips

The surface that cells grow on has a significant impact on their behavior. Studies have proven that cells orient themselves relative to topographical features even down to nanoscales, a phenomenon

Reproducibility and Extraction of Complex Hydrogel Geometry Fabrication in 3D Printed Injection Molds

Type 1 diabetes is an autoimmune disorder characterized by the destruction of pancreatic islet cells which results in patients no longer generating their own insulin. Islet cell transplantation via macroencapsulation

Replication of a Two-Axis Robotic Platform for Improved Ankle Characterization and Postural Stability Studies

Understanding the human ankle and neuromuscular disorders like multiple sclerosis and stroke are very important in field of rehabilitation and lower-limb prostheses. This research tracks the replication of a two-axis

Hyunglae Lee and Connor Phillips

Muscle Response During Multidirectional Interaction with a Variable Damping Controlled Ankle Robot

Robotic exoskeletons have tremendous potential for implementation in defense, industrial factories, and medical rehabilitation. However, current systems rely primarily on negative damping controllers which although safe, are very slow and

Observing Effect of Orientation, Location, and Threshold of TMS Coil on Motor Cortex Activation

Transcranial magnetic stimulation (TMS) is a form of non-invasive brain stimulation proven to have various clinical applications. This study examined the effects of (1) the TMS coil orientation during stimulation

Engineering Novel Microbead Encapsulated Three Dimensional Tumor and Stem Cell Models for Regenerative Medicine

Two-dimensional culture and entrapment of cells have been long studied using ECM-induced, cell-signaling induced, and biochemical-induced modes. But the significant efforts in recent years have demonstrated the advantage of three-dimensional

Variable Impedance Control of the Robotic Ankle Joint

This study introduces a variable impedance controller for implementation in wearable robots. The controller applies a range of robotic damping and stiffness to the coupled human-robot system based on the

The Effects of Heat Treatment on the Drug Loading of Poloxamer Micelle Structures

The research motivation was to study the effects of heat treatment on the drug loading of poloxamer micelle structures. This project also investigated the stability of the heat-treated micelles in

Characterizing Nanocomposites for Customizable Cartilage Replacements

The properties and characteristics of photocurable nanocomposites can be tailored to mimic those of various tissues and/or cartilage, allowing the bio-inspired synthetic material to replace them. The long-term goal of

Creation of AD-Relevant Isogenic Lines with CasMasTREE

Since 1901, Alzheimer’s disease (AD) claims at least 5.5 million individuals each year, making it the sixth leading cause of death in the United States. Due to the pandemic, research

Making Portable and Less Expensive Fluorescence-Based Spectrometer for Monitoring the Quality of Olive Oil

Olive oil is a source of vitamins to aid in the proper growth and healthy growth of the human system, however, determining the quality of olive oil with a cheap

Design and Testing of 3D Printed Multimaterial Structures for Energy Absorption

The objective of this study was to design, manufacture and test multi-material 3D printed cellular structures under compression, to evaluate their suitability as energy absorbers. The role of wall thickness

Developing a Solar Powered Automatic Chlorine Sensor For Use in Developing Nations

Chlorination is the most common approach to disinfecting water, however it requires a precise concentration level to work effectively. Determining how much chlorine to add is often difficult for these

Risk Analysis of Antibiotic Resistant Genes Transferred to Raw Vegetables via Land Application of Biosolids

In agriculture, various forms of recycled water are utilized to compensate for the scarcity of freshwater, including wastewater reuse in the form of biosolids. However, biosolids pose risks to human health and

The Development of Geometries for a Passive Check Valve in Patients with Hydrocephalus

Hydrocephalus (HCP) is a chronic, congenital neurological disorder. Faulty arachnoid granulations inhibit the draining of cerebrospinal fluid (CSF) across the interior subarachnoid space leading to an accumulation of CSF in

Understanding the Effects of Gait Adaptation from the Combination of Visual and Split-Belt Distortion

Split-belt distortion is one method of increasing the effectiveness of traditional treadmill rehabilitation, where the patient recovers more quickly through targeted rehabilitation of their paretic leg. Visual distortion has been

Directed Evolution for Biological Sensors

Complex synthetic biology methods demand the integration of continuous culture, directed evolution, and positive/negative selection methods. To achieve this in a single platform, the research team built an open source

Phage Assisted Continuous Evolution (PACE) with PhiX174

Phage assisted continuous evolution (PACE) is the most current and advanced method of protein engineering, allowing for accelerated development and complex functions. The research team sought to explore opportunities for

Synthesis of Covalent Organic Frameworks (COFs) for the Purpose of Encapsulating and Releasing Glaucoma Drugs

Drug delivery methods can be demanding on the patient and require them to administer drugs on their own. This is demanding and tedious on the individual. Covalent Organic Frameworks (COFs)

Practical Applications for Fluorescence Spectroscopy

The research is aimed at exploring diverse applications of fluorescence spectroscopy. Using a portable inexpensive (<$ 20.00) UV/VIS/IR optical spectrometer system designed by the SciHub laboratory, the research focused on

Extending the Use of a Portable Spectrometer to Measurement of Photo-Luminescence

The research focused on designing a variant of a portable device (spectrometer) that can possibly help in identifying the nature of an object/substance. For example, identifying whether someone’s skin is

Towards Automated Identification of Cancer Immunotherapy Targets: Prediction of Binding Affinity of T Cell Receptor and Antigens Using Graph-Guided Deep Neural Network

Cancer can be treated through immunotherapy, a personalized treatment to train a person’s own body to create an immune response towards cancer cells. The problem arises in understanding when a

Investigating PEG-Polyurethane as the Basis of Bone Scaffolding Technology

Bone scaffolding technology assists in the repair of major segmental bone injuries by mimicking the structure and function of the natural bone extracellular matrix. Potential for design improvement can be

Adaptable Multi-Modality Nanoprobes for Non-Invasive Real-Time Monitoring of Engineered Cells and Tissues

A versatile method for assessing cell and tissue viability in different culture systems remains a concern in the large-scale biomanufacturing industry. In this project, the research team utilizes the advantages

Improvements on the design of spinneret extruder

The objective of this research is to design of spinneret (extruder) that can consistently produce small diameter carbon fibers (CF) using the island-in-the-sea configuration.

Sensing and Controls of an Assistive Knee Exoskeleton

Assistive exoskeletons are an increasingly valuable rehabilitation tool for patients with neurological damage. However, high level assistive control of exoskeletons remains a challenge. Many different sensors must work in concert

Deep Brain Stimulation

Deep-brain-stimulation (DBS), which is a clinical intervention for Parkinson’s disease, research was done on development of a system which would use cerebral blood flow rates and their changes to optimize

Arteriovenous Malformations

Arteriovenous Malformations (AVM) are tangles of blood vessels connecting arteries and veins in the brain, that disrupt blood flow and can cause irreversible brain damage. Treating AVMs is currently flawed,

Activity-Dependent Neuroplasticity Model in Response to Applied Electrical Stimulation

This research is investigating the effect of applied electric potential on synaptic plasticity in neural networks. Applied current can activate neurons in a manner that can induce activity-dependent plasticity, i.e.

Using Stem Cells and Hyaluronic Acid Hydrogels to Increase Cortical Plasticity Following TBI

Advances in stem cell technology have shown promise for treating traumatic brain injury (TBI). We tested the effects of injecting neural stem cells embedded in a hyaluronic acid hydrogel on

Biochar’s Ability to Remove Escherichia Coli

The research question addressed was how effective biochar is as a soil amendment for the removal of Escherichia Coli (E. coli). Biochar is created through pyrolysis – heating biomass in

Silicon Netting for Surgical Organ Isolation

Laparotomies surgeries are performed to explore and examine a patient’s abdominal cavity to diagnosis any issues or complications a patient may present with. An issue with laparotomy surgeries is maintaining

MedTech Surgical Device Innovation for Trapped Lung

Trapped lung is a condition in which the lung cannot expand fully due to a fibrous “peel” that restricts expansion. There are no surgical devices designed specifically for fibrous tissue

Creating a Multi-Modal Near Infrared Photoacoustic Fluorescence Microscopy System for In Vivo Imaging

Current optical imaging techniques have a limited penetration depth based on the high attenuation of visible light in biological tissue. Fluorescent and photoacoustic microscopy are methods currently used to explore

Design and Characterization of Variable Stiffness Soft Actuators for Lateral Ankle Support

This research explores the design of a soft robotic ankle-foot orthosis (SR-AFO) exosuit designed to support the ankle in the inversion and eversion directions without restricting motion in the dorsiflexion

Gait Sensing using Fabric based Soft Inflatable Actuators and Force Haptic Feedback

The physical therapists commonly make use of their visual prowess to ensure that the patients adapt correct walking patterns by observing for postural abnormalities and cuing when necessary. For better

Investigating Factors to Provide Sustained Release of Ketorolac in Temperature-Responsive Hydrogels

Local delivery of anesthetics are a safer alternative to postoperative pain management than opioids, which can have addictive and dangerous side-effects. This research aimed to address postoperative pain via sustained,

Effect of Growth-Feedback on Adaptive Synthetic Gene Circuits

Synthetic gene circuits are designed with different network topologies to give cells specific functions. These functions are affected by circuit-host interactions such as resource competition, cell growth-mediated feedback, and metabolic

Magnetic Needle Steering for Minimally Invasive Surgery

This research aims to provide surgeons with a way to conduct more complex surgeries with increased precision and control in a minimally invasive manner. By utilizing a robotic arm to

Utilizing Histone Deacetylase Inhibitors (HDACi) to Alleviate Traumatic Brain Injury (TBI) Pathology

Following traumatic brain injury (TBI), the body initiates pro-inflammatory responses which in excess, may lead to neurodegeneration. Recent studies report histone deacetylases (HDAC) as a key player in modulating neuroinflammation,

Development of the SmartPad System for Energy Expenditure Detection

Energy Expenditure (EE) is the energy organisms utilize to carry out their cognitive and physical actions. A mismatch between EE, energy storage, or energy intake can lead to a variety

Verification of Ratiometric pH Sensing PHPMA-Derived Polymer in Human Neuronal Tissue Models.

Assessment of the cellular microenvironment is important to examine organ and cell function. The PHPMA-derived polymer can be used as in-line method to use pH levels to test the cellular

Towards a Software Package that Improves Planning of Great Artery Heart Defect Surgeries

Great artery heart defects (GAHDs) are a trio of severe congenital defects that cause poor systemic oxygen delivery, ventricular enlargement, and is fatal if untreated. All three of the conditions

High Speed 3D Printing of Portable Microscope Lens via Micro-Continuous Liquid Interface Printing

The aim of this research is to be able to 3D-print an optical lens via micro-Continuous Liquid Interface Printing (µCLIP). Manufacturing lenses right now is a lengthy process, it takes

Design Optimization of the Active Ankle-Foot Orthosis (AAFO)

The objective of this project was to optimize a rigid, motorized ankle-foot orthosis (afo) to assist in the rehabilitation process for people suffering from neuromuscular conditions that impair ankle-foot mobility.

Bioengineered Space-Like Protein Crystals on Earth: Implications to Regenerative Medicine

Regenerative medicine (RM) shows the possibility to regenerate 3D tissue and organs from cells given an appropriate extracellular microenvironment. A better understanding of the structure-function relationship between cell surface proteins,

Oral Drug Delivery Vehicle for Prevention of Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic joint-inflammatory autoimmune disease that affects 0.5-3.3% of the population worldwide. This project aims to engineer an oral drug delivery system that can modulate intestinal

The Effects on Lower Motor Neuron Degeneration and Neurodegeneration Within the Cervical Region of the Spinal Cord Twenty-Eight Days Post Traumatic Brain Injury

This project’s motivation is to determine the extent that traumatic brain injury (TBI) affects lower motor neuron degeneration and neurodegeneration within the cervical region of the spinal cord twenty-eight days

Quantification of Tissue Oxygenation to Improve Encapsulated Cell Viability In Vivo

The long-term goal of this research is to transplant encapsulated beta cells into a diabetic recipient and eliminate insulin injections. Beta cells succumb easily to hypoxic environments. To test oxygen

Epileptic Seizure Detection and Prediction

Epilepsy is the 3rd most common neurological disorder in the United States. Despite continuous research efforts, 30% of those with epilepsy have uncontrolled seizures, and its unpredictability can become disabling.

Cas9 Mediated Adenosine Transient Reporter for Editing Enrichment

CRISPR/Cas9 systems can be used to edit induced pluripotent stem cells to create nearly any genomic edit for disease-modeling. However, there is no readily available phenotype to enrich for edited

An Expandable Retractor Tool for Increasing Available Working Space During Neurosurgery

An estimated 23,890 adults in the United States will be diagnosed with cancerous tumors of the brain and spinal cord in 2020.  However, while tubular retractors allow neurosurgeons to reach

Needle Tracking System

The motivation for the project is to design a method for tracking a needle, steered by permanent magnets, inside the human body while performing targeted drug delivery. A small tube

Development of Active Movement-Damping Mechanism for Implementation in Knee Brace

It is projected that 100,000 people rupture their anterior cruciate ligament (ACL) annually in the U.S. Knee braces are commonly used in conjunction with intensive physical therapy to aid the

Modeling of Environment Dependent Modulation of Ankle Impedance During Walking

The motivation for this research is to model the impedance of the human ankle during walking in variable environments. In order to characterize ankle impedance, subjects walk over a robotic

A Self-Fluctuating Prosthetic AirActuator Liner With A Soft Memory Foam Design for Lower Limb Amputees to Improve Comfort, Stability, and Fluctuation in Prosthetic Sockets

This research can help amputees with constant fluctuation of volume inside the sockets, rather from amputation, prolonged walking, or exercising. The idea behind this device with an emphasis on comfort

Variable Impedance as Control Scheme for Enhanced Performance and Stability of Active Ankle Foot Orthosis

Human walking is associated with exertion that results in muscle fatigue. This fatigue is a key parameter in determining deviation of an abnormal gait. But, accurate forces to an abnormal

Development of a Neuromuscular Electrical Stimulation Control System For Hand Muscle Therapy

Individuals with Spinal Cord Injury (SCI) have healthy muscle cells but the communication between the muscle and brain has been lost. Muscles that are paralyzed or partially paralyzed can be

Using a Wireless Electronic Platform as Part of a Smart Knee Brace to Aid Rehabilitation and Prevent Anterior Cruciate Ligament Reinjury in Athletes

Anterior cruciate ligament (ACL) tears are one of the most common knee injuries among American athletes with up to 250,000 incidents per year. The objective of this project was to

Temporal Specificity of the Binding Potential of CDR3 Peptides to Traumatic Brain Injury

The goal of this project is to discover new biomarkers for traumatic brain injury (TBI) in hopes of improving diagnostic tools for this condition. Immunohistochemical evaluation will be used to

Analysis of Anterior Cruciate Ligament (ACL) Forces to Prevent ACL Tears

There are approximately 200,000 ACL tears a year solely in the United States. With such a high volume of ACL injuries occurring every year, it is vital to find a

Engineering an Encapsulated 3D Tumor Dormancy Model In Vivo Using NRAS-Mutant Melanoma Cells

Two-dimensional entrapment of tumor cells to study dormancy has been studied before using ECM-induced, cell signaling-induced, biochemical-induced, etc. modes for cancers such as prostate, lung, colorectal, pancreatic, etc. in vitro,

Quantifying Muscular Response During Physical Human-Robot Interaction With a Variable Damping Controller

Robotic exoskeletons have tremendous potential for implementation in defense, industrial factories, and medical rehabilitation. However, current systems rely primarily on negative damping controllers which although safe, are very slow. In

Thermo-Responsive pNIPAAm-Based Polymers for Endovascular Brain Aneurysm Repair

Each year, approximately 30,000 people in the United States experience a ruptured brain aneurysm. A current treatment is endovascular therapy, which use coils and/or stents to divert blood flow. poly(N-isopropylacrylamide)

DNA Repair Capacity of NRAS-Mutant Melanoma 3D Spheroids Under Oxidative Stress and DNA Repair Inhibition

B-Raf inhibitor resistance in NRAS-mutant melanoma cells results in poor prognosis and aggressive clinical behavior. Currently, there is a need for therapies that circumvent this resistance in NRAS-mutant melanoma. This research describes

Monodispersity of PLGA Microparticles

In microsphere drug delivery systems, the monodispersity of microparticle determine the rate of drug release and the rate of biodegradation, which are important for patient health. This experiment looked into

Understanding the Effects of Gait Adaptation from the Combination of Visual and Split-Belt Distortion

Split-belt distortion increases the effectiveness of traditional treadmill rehabilitation through targeted rehabilitation of their paretic leg. Visual distortion is another method that has been used in previous studies to greatly

Modification of Synthetic Hydrogel Chemistry to Generate Complex Macroencapsulation Device Geometries

Islet cell replacement via transplantation is a promising therapy to restore blood glucose regulation in patients afflicted by type 1 diabetes mellitus, but is limited by the need for multiple

Loperamide Encapsulated Nanoparticles for Evaluating Blood Brain Barrier Permeability Post-Experimental Traumatic Brain Injury

Due to traumatic brain injury (TBI) presenting with extensive treatment challenges, this study created nanoparticles to evaluate the pharmacokinetics/pharmacodynamics associated with drug delivery in a compromised blood-brain barrier. Loperamide encapsulated

Functionality of Octopus Arm Muscles

The purpose of this research project is to determine the functionality of each muscle group in an octopus arm. Quantitatively tracking the complex motion and electromyography signals produced by an

2D Variable Damping Control of the Robotic Ankle Joint to Improve Trade-off between Agility and Stability and Reduce Effort

This study introduces a two-dimensional variable damping controller for implementation in wearable robots. The controller applies a range of robotic damping between negative and positive to the coupled human-robot system.

Discovering Factors That Drive the Migration of Immune Cells Into Malignant Pleural Mesothelioma Tumors

The goal of this research was to map the network of interactions influencing immune cell migration. A series of filters were applied to a transcriptional regulatory network to prioritize a

Development of Surgical Device to Aid in the Decortication Procedure for a Trapped Lung

Infections, pulmonary embolisms, autoimmune disorders, lung cancer, and surgeries can lead to a fibinous pleuritic, or inflammation of the membrane that surrounds the lungs. This can trap the lung, preventing

Reproducibility and Completeness of Complex Hydrogel Geometry Fabrication in 3D Printed Injection Molds

Type 1 diabetes is an autoimmune disorder characterized by the destruction of pancreatic islet cells which results in patients no longer generating their own insulin. Islet cell transplantation via macroencapsulation

Targeting B-cell lymphoma through the use of CAR macrophages

B cell lymphoma is a cancer of the white blood cells, which develops when the body starts making abnormal B cells. Abnormal B cells hinder the body’s ability to fight

Investigating the Role of Astrocytes on GSC Invasion In A 3D Microfluidic Vascular Tumor Model

Glioblastoma Multiforme is the most aggressive cancer that begins within the brain. They can either start from normal brain cells or develop from an existing low-grade astrocytoma, and are housed

Wireless ECoG (Electrocorticography) for Intra-operative Neurophysiological Monitoring

Glioblastoma Multiforme (GBM) is the most common central nervous system tumor with short life expectancy and only a limited number of patients survive more than three years following diagnosis. During

Collecting Data to Determine if Startle Correlates to a Successful Step Response in Stroke Survivors

This research involves processing data to understand if startle is linked to the mechanics of a proper step response in order to prevent falls in stroke survivors. The research team’s

Towards Portability of Pneumatic Wearable Devices using Low-Volume Inflatable Actuator Composites and a Portable Pneumatic Source

Common drawbacks of pneumatically-actuated soft wearable devices include tethered air supplies and slow actuation speeds. The design of efficient and portable soft-pneumatic systems necessitates new soft actuators and pneumatic sources.

Investigation of Sex Differences in 2-Dimensional Ankle Stiffness During Upright Standing

Studies have shown a huge gender gap in ankle stability and increased incidence of ankle injury in females as compared to males, however, there is little information regarding the neuromuscular

BrainTracker mHealth Application: Monitoring the Comorbidities of Pediatric Neurological Disorders

Children with chronic disorders such as epilepsy are at an increased risk for cognitive and psychosocial problems. Clinical assessments of these comorbidities are resource-intensive and typically not gathered from a

Functionality of an Octopus Arm

The purpose of this research project is to determine the functionality of each muscle group in an octopus arm. Quantitatively tracking the complex motion and electromyography signals produced by an

Development of a Neuromuscular Electrical Stimulation Control System For Hand Muscle Therapy

Individuals with Spinal Cord Injury (SCI) have healthy muscle cells but the communication between the muscle and brain has been lost. Muscles that are paralyzed or partially paralyzed can be

Magnetic Needle Steering for Minimally Invasive Surgery

This research aims to provide surgeons with a way to conduct more complex surgeries with increased precision and control in a minimally invasive manner. By utilizing a robotic arm to

The Impact of a Startling Acoustic Stimulus and Transcranial Magnetic Stimulation on Reaction Times in Unimpaired Older Adults

An unexpected loud noise known as a Startling Acoustic Stimulus (SAS) can cause a startle reflex response, which has been shown to enhance movement in stroke patients [1, 2, 3].

Role Adaptation in Robots for Effective Physical Human-Robot Interaction

Modern robotic devices are required to perform certain tasks where they need to teach actions to humans through haptic/physical interactions, e.g., rehabilitative robots. For achieving that, a simulation study, with

Wireless, Fully Passive, Multi-Channel Neural Recorder

One in five people in the United States alone suffer from neurological damage which can lead to complications such as cerebral palsy, Parkinson’s disease, and many other disorders. However, while

Epileptic Seizure Detection and Prediction

Epilepsy is the third most common neurological disorder in the United States. Despite continuous research efforts, 30% of those with epilepsy have uncontrolled seizures, and its unpredictability can become disabling.

Using Salmonella as a pH-modulator to Explore the Tumor Microenvironment

Cancer treatments such as chemotherapy and radiation are expensive, painful, and often ineffective, as they compromise the patient’s immune system. Genetically-modified Salmonella typhimurium (GMS) strains, however, have been proven to

A Self-Fluctuating Actuator Air Prosthetic Liner With Memory Foam Design for Lower Limb Amputees to Improve Comfort, Stability, and Fluctuation in Prosthetic Sockets:

The question being presented is could this device replace stump socks as well as socket fillers to help amputees with the constant volume fluctuation inside their sockets, rather fresh amputation,

A Force-Tracking Restraint System for Novel Movement and Sensation in Virtual Reality

Despite significant advancements in the visual side of virtual reality (VR) due to improved headset technology, physical movement and sensation in VR have yet to be effectively implemented. The physical

Modification of Synthetic Hydrogel Chemistry to Generate Complex Macroencapsulation Device Geometries

Islet cell replacement via transplantation is a promising therapy to restore blood glucose regulation in patients afflicted by type 1 diabetes mellitus, but is limited by the need for multiple

Study of How Yeast Transport in Membrane Protein

Protein transporter Sul1 and Sul2 in yeast is similar to those in human gene family SLC26. Thus, identifying the mutations in Sul1 and Sul2 can guide scientists to discover what

Synthesis of Calcium Phosphate Nanoparticles with the Inclusion of Metabolites and Ovalbumin

Cancer is a life-threatening disease that involves uncontrolled cell growth. This project aims to inhibit glucose metabolism that feeds the cancer cells and cause the cells to proliferate by using

Discovering Factors that Drive the Recruitment of Macrophages to Glioblastoma Multiforme Tumor Cells

Currently, the researcher is working to produce a list of biological factors that may drive immune cell migration to Glioblastoma tumor cells. Discovering these factors may lead to improved quality

Development of Electrospun 3D Biomaterials

The motivation for the research conducted over the summer semester was to understand the mechanical properties of three-dimensional electrospun rolled scaffolds made from Polycaprolactone. To determine how scaffold thickness may

Needle Tracking System

The motivation for the project is to design a method for tracking a needle, steered by permanent magnets, inside the human body while performing targeted drug delivery. A small tube

Effects of Startle-Evoked Movement Associated with Learning a Novel Motor Task

Startle-evoked movement (SEM) is shown to trigger a fast and accurate motor task. The learning process and the startle response are involved with the same circuitry within the brain, yet

Ankle Flexion Data as a Differentiative Measure in Orthotic Device Prescription for Stroke Survivors

Gait and balance impairments are well-known consequences of a stroke that causes nearly half of the 6.5 million stroke survivors in the U.S. to fall. Ankle Foot Orthoses (AFOs) are

Development of Biomanufacturing Unit Operations for Human Cell Therapy (HCL) Good Manufacturing Practices (cGMP)

Regenerative medicine (RM) is an emerging technology being developed by scientists, engineers, and clinical specialists to revolutionize medicine. As humans lose tissues and organs due to injury or disease, it

Treatment of Acute Upper Gastrointestinal Clots Through Histotripsy

Acute upper gastrointestinal (GI)  bleeding results in 20,000 deaths annually in the United States. The issue with acute upper GI bleeding is locating and removing an excessive amount of blood

Treatment of Acute Upper Gastrointestinal Clots Through Histotripsy

Acute upper gastrointestinal bleeding results in 20,000 deaths annually in the United States. The current issue is in locating and removing an excessive amount of blood clots obstructing the location

The Adaptive Omphalocele Protective Device

The Adaptive Omphalocele Protective Device is a novel medical device created in partnership with Phoenix Children’s Hospital (PCH), which helps families safely transport their children born with an omphalocele birth defect. An

Design and Control of a Soft Robotic Ankle-Foot Orthosis

For physical therapists working with patients with foot and ankle injuries, it is imperative that they have mechanical help with the rehabilitation process. However, existing solutions are cumbersome and stationary.

Octopus Arm Muscles in Relation to Arm Use for Bioinspired Robotics

The objective is to study the musculature of Octopus arms for use in Bioinspired Robotics.  Previous literature presents the idea of uniform muscle layering. The lab has found this not

Cranial Crown: A Pediatric Headset for Transcranial Doppler

Transcranial doppler can be used to detect seizure and stroke during cardiac surgery. There is currently no feasible transcranial doppler headset for use on pediatric patients in the operating room.

Research for development of A Self-Fluctuating Actuator Air Prosthetic Liner with Memory Foam Design for Lower Limb Amputees to Improve Comfort, Stability, and Fluctuation in Prosthetic Sockets:

The research question that is being proposed is whether an air-based device can address volume fluctuation inside a prosthetic socket for lower limb amputees. The main objective will be to

Collapsible, Large Scale 3D Printer

Medical professionals and relief workers around the world are faced with new and complex challenges regarding their patients’ health. Additive Manufacturing has the capability to assist with many of these

Investigating the Role of SP5 in WNT Signaling Using an In-Vitro Model of Neural Patterning

This project attempts to better understand how the WNT transcriptional program is affected by β-catenin and SP5 by developing an in vitro model of neural patterning. This signaling pathway uses

Developing a Model to Detect and Analyze the Presence of Important Emergency Care Factors via Twitter

Analyzing social media can offer insights into a wide range of topics that are commonly discussed online, providing valuable insights for tracking emergency care factors – medical conditions which may

Analysis of Sul-1 and Sul-2 Transporters on Sulfur Uptake and Cellular Growth

The goal of this research is to prove that a certain gene in yeast cells provide code for a transport protein that carries sulfur, a necessary nutrient, into the cell.

Cloning Antibodies to Understand Neurodegenerative Diseases

Neurodegenerative diseases are still widely misunderstood, but are believed to be caused by the production of β-amyloid peptides (Aβ). Single Chain Fragment Variables (scFv) antibodies can be used to eliminate

Production of NorHA Microspheres for Peptide Tethering

Tissue engineering is an essential part of regenerative medicine. For bone regeneration, scaffolds are used as ways for inducing stem cell proliferation/differentiation, and drug delivery. Current scaffolds are bulky and

Electro Supn Rolled Scaffolds

The research that is being conducted for this project focuses on turning 2-dimensional electro-spun scaffolds into 3-dimensional scaffolds. Four samples at three different time values. The researcher then transformed these

Qurry: A Quantum Probabilistic Programming Language

Quantum programming languages are a relatively recent innovation which allows arbitrarily accurate modeling of the physical world. However, these languages are largely still in early development: any lack of true

MisophoniAPP

The purpose of this project is to introduce MisophoniAPP, a new website for managing misophonia. It will briefly discuss the nature of this chronic syndrome, which is the experience of

Comparing Protocols for Extracting, Amplifying, and Imaging ApoE ε4 Allele: Preliminary work for understanding Alzheimer’s Disease in asymptomatic individuals

This project aimed to develop a consistent protocol used to effectively image the apolipoprotein E (ApoE) 4 allele, which is a known genetic risk factor for Alzheimer’s Disease (AD). The

Active Thermoregulation for Transtibial Prosthetic Sockets

Transtibial amputation is the most common type of major lower limb amputation.  With approximately 2 million current amputees and 185,000 new cases each year due to vascular diseases (diabetes) in

Modeling Carriers and Biological Specimen Utility of a Molecular Diagnostic Biosensor for Navajo Neurohepatopathy

Navajo Neurohepatopathy (NNH) is caused by a single nucleotide polymorphism (SNP) and is fatal to the 1 in 1,600 Navajo children affected. To confirm positive NNH diagnoses, clinicians need to

Improving Treatment of Varicose Veins through Adjustable Compression

Varicose veins affect about 20% of the United States’ population at some point in their lives, causing swelling, blue or purple discoloration, cramping, itching, and burning. The goal of this project

Characterization of Human Myocardial Tissue Model on a Microfluidic Device

Myocardial infarction is the most prominent cause of heart failure in the U.S. affecting 5.8 million people yearly. Despite the increasing number of affected, there is a lack in understanding

The Effects of Startle Evoked Movement on the Learning Associated with a Novel Finger-Abduction Task

Startle evoked Movement (SEM) has triggered muscle movements in previously paralyzed muscles. Another study has shown improved learning within a one-week training period for individuals completing a novel motor task.

Upper Extremity Orthotic Medical Device to Facilitate Movement for Individuals with Muscular Dystrophy

Muscular dystrophy is a group of genetic diseases caused by mutations or abnormal genes that progressively results in weakness in or loss of muscle mass. Due to a degradation of

Ultrasound-mediated Drug Delivery with Poly(N-isopropylacrylamide)-based Polymers

Ultrasound-enhanced polymer degradation is used to improve the quality and rate of polymer degradation and the polymer’s ability to release encapsulated substances. The goal of this research is to study

Development of Flourcent Siloxane Nano-probes as an In-Line Assay of Cell and Tissue Function

 A live method to test the functionality of cell culture and tissue is needed to assess the growth of cells for further in-line applications. Fluorescent oxygen sensing siloxane nanoprobes provide

Novel Nanoparticle System to Treat Traumatic Brain Injury

Each year 5.3 million Americans are living with a traumatic brain injury (TBI)-related disability and another 1.4 million individuals suffer from a TBI. The objective of this project was to

Ultrasound Cleavable Polymers for Reversible Vascular Embolization

Embolization therapy uses either particles, metal coils, or balloons to reduce blood supply to a targeted area, starving cancerous tissues. This proposal focuses on creating a polymer that can change

Using 1H MRI Reporter S-Gal® to Study Senescent and Quiescent Cells

Senescent and quiescent cells are cells that stop proliferating due to a variety of factors, including stress-induced senescence. Recognizing these cells through MR imaging can help detect dormant  cancer tumors.

Impact of Electrospun Nanoscaffold Morphology on Cell Fate to Optimize Tissue Regenerative Response

The research objective is to fabricate tunable electrospun nanoscaffolds and analyze their morphology to determine if it is feasible to design an implantable 3D substrate to induce tissue regeneration. Prototypical

Liquid Embolic Synthesis for Aneurysm Occlusion

The objective of this research is to create an injectable liquid embolic that can degrade as tissue is regenerated for the treatment of cerebral aneurysms. To achieve this, a Michael

A Combined Optical and Electrical Probe for Electrophysiology

Electrical recordings of individual neurons deep within the brain are key to enhancing understanding of neuronal dynamics. Unfortunately, optical microscopy, which is used to visualize neurons during the recording process,

Tyrosine Infused Micro Particles

The goal of this research is to encapsulate tyrosine in microparticles and determine the release rate to find the desired concentration to encapsulate. After designing a protocol to create microparticles,

Optimizing Recombinant Protein Production for Domain Antibodies: Proof-of-Concept

Recent studies in traumatic brain injury (TBI) have found a temporal window where nanometer scale therapeutics can cross the blood-brain barrier into the parenchyma. Development of recombinant antibody production is

Development and Assessment of a Diagnostic Tool to Detect and Genotype Navajo Neurohepatopathy

Navajo Neurohepatopathy (NNH) is a fatal genetic disease that impacts 1 in every 1,600 Navajo children below the age of ten. This disease is caused by a single nucleotide polymorphism

Feasibility of Dielectric Elastomer Actuators in Lower Limb Prosthetic

The purpose of this study is to determine the feasibility of using dielectric elastomer actuators (DEA) for powering prosthetic feet. DEAs are essentially a deformable capacitor and previous studies have

Diffusion of Dextran Across a Microfluidic Device Used to Model Native Myocardium

Every year, myocardial infarction (MI) is responsible for over 25% of all global deaths and is expected to increase due to the oncoming obesity epidemic. Despite the unworldly lethality of

Utilizing Siloxane-Based Nanoprobes for the In-Line Monitoring of Neural Progenitor Cells In-Vitro

Alzheimer’s disease (AD) is one of the top leading causes of death in the U.S. Cell therapies for AD using neural progenitor cells (NPC) have been tested, but it is

Assistive Walking Device for Gait Disorder Patients

This objective of this research is to create a device that will assist those with drop foot and other ankle-based gait disorders. The device must provide enough assistive force to

Development of an OpenSim Simulation to Identify Time and Force Magnitude Needed at Toe-Off Stage for an Assistive Force Ankle Device

Human walking is a complex and rhythmical activity that comprises of the brain, nerves and muscles. Neuromuscular disorder (NMD) is a broad term that refers to conditions that affect the

Balancing of a Stationary Bicycle Using a Control Moment Gyroscope

By intuition, people steer their vehicles to the desired direction. However, on a bicycle, the gyroscopic force of the front wheel creates an angular momentum that will lean the vehicle

Investigating Application of TPU-Coated Soft Fabric Actuators in Soft Poly-Limbs

The focus of this research is to design and fabricate a Soft Poly Limb (SPL) using soft Thermoplastic Polyurethane (TPU) coated fabric actuators. After several ASTM standard tests, Rockwood’s 200D

Detection of Heel-Off Initiation Based Correlation Between Ground Reaction Forces and Lower Extremity Surface Electromyography

The objective of this project was to identify heel-off and toe-off during gait based on the correlation between ground reaction forces (GRF) and surface electromyography (sEMG) of lower extremity muscles

Smart Bike Human-in-the-Loop Control

Bicycles are used for daily transportation by a large share of the world’s population; however, riding a bicycle may be inconvenient or impossible for persons with disabilities. The goal of

A New Step Forward

The objective of this project is to develop a device that assists gait.  Assistive devices for a treadmill can help in gait rehabilitation for stroke survivors. This rehabilitation set up

Wireless Wearable Respiratory Monitor

Respiratory health is something that many people do not consider in their daily life, yet asthma is becoming increasingly more common in people of all ages. In order to properly

Improving Offset Electrospinning for the Tendon-Bone Junction

Approximately 2 million Americans experience a torn rotator cuff each year. The healthy rotator cuff is a complex tissue consisting of opposing biochemical gradients. This research aids the advancements of

Collecting Data for Pressure Ulcer Monitoring and Prevention System

In 2014, pressure ulcers affected approximately 2.5 million people in the United States. These blisters form in bony prominences in bed-bound patients. If untreated, these ulcers worsen until they become

Magnetic Needle Steering for Minimally Invasive Surgery

The applications of robotics in surgery has allowed medical professionals to perform more complex, minimally invasive surgeries with increased precision and control. While most robotic systems are used simply to

Variable Damping Control of Robotic Ankle Joint to Improve the Tradeoff Between Performance and Stability in the Frontal Plane

The growing demand for physically interactive robots for industrial, medical, and military applications is succeeded by a demand for better performing and more transparent human-robot systems. This research explores the

Utilizing Human Induced Pluripotent Stem Cells Conjugated to Biocompatible Gold Nanorods to Enhance Synchronous Beating and Functional Characteristics Similar to in vivo Cardiac Tissue

Myocardial infarction (MI), also known as heart attack, is one of the main causes of death in the United States. Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) are

Investigation of Underlying Mechanisms for the Modulation of Multi-dimensional Ankle Stiffness

Characterization of multivariable ankle stiffness is important for better understanding how the ankle supports lower-extremity functions. The purpose of this research project is to further investigate the underlying mechanisms for

Sex Differences in Voluntary Control Dynamics of the Knee and Ankle

Ever since Title IX in 1972, females have been known to have an increasingly higher rate of musculoskeletal injuries occurring while playing sports than in males. This study focuses on

Applying Developmental Biology Principles to Probe the Mechanisms of Selective Cell Vulnerability in Alzheimer’s Disease Using Human Induced Pluripotent Stem Cells

Alzheimer’s Disease (AD) affects over 5 million individuals in the US. The idea behind selective cell vulnerability in AD and various amyloid-dependent have been postulated. However, such mechanistic studies do

Non-invasive Cellular Detection Using the Photoacoustic Effect

The photoacoustic effect occurs when a target absorbs a specific wavelength of light, resulting in thermal expansion and the production of subsequent pressure waves. This phenomenon can be used in

Senescence Phenotype Analysis of Progerin Induced Alzheimer’s Disease Neural Progenitor Cell Line Using Confocal Microscopy

The caveat of using a human induced pluripotent stem cell (hiPSC) model for studying any late onset age progressive disorder like Alzheimer’s Disease (AD), is the loss of age-associated makers

Video Motion Magnification to Enhance Speech of Patients with Deteriorated Speaking Ability

The project aims at using degraded speech as well as visual information to improve speech generation. ALS and Parkinson’s are one of the more dreadful diseases where people lose the

Pressure Ulcer Monitoring and Prevention System Algorithm

Machine learning algorithms used in biomedical applications indicate the ability of a medical device to make decisions similar to a physician. For this research, the researcher aims to address the

Design and Characterization of Programmable FRET Biosensors

Fluorescence Resonance Energy Transfer (FRET) is a physical phenomenon that is being used in biomedical research and drug discovery. Using fluorophore-labeled DNA nanostructures, researchers characterize the FRET efficiency of a

Building a HEK293T Reporter Cell Line to Study Gene Expression

Through the course of development, human cells successfully differentiate into hundreds of different cell types. A better understanding of cell differentiation could have applications in relation to regenerative stem cell

Deep Learning of Brain Images for Classifying High-Risk Alzheimer’s Disease Population

Researchers investigated that current methods for clinical diagnosis of AD are suboptimal. In recent years, the application of deep learning techniques to AD diagnosis has been broadly investigated due to

Understanding the impact of breast cancer cells/ fibroblasts co-culture on inducing M2 macrophages in a 3D in vitro model.

Understanding the impact of the breast cancer microenvironment on progression will help with future cancer treatments.

Variable Damping Control of the Robotic Ankle Joint to Improve Trade-off between Performance and Stability

Developing an advanced controller to balance agility and stability in a wearable ankle robot will maximize performance for the user.

Using 1H MRI Reporter S-Gal® to Study Senescent and Quiescent Cells In Vitro

Finding a molecule that can identify dormant cancer cells will help develop better tumor characterization and treatment.

Voluntary Response Mechanics of the Human Ankle

Forming mathematical models to describe ankle mechanics can assist in developing advanced lower limb prosthetics.

Ultrasound Cleavable Polymers for Reversible Vascular Embolization

Synthesizing a polymer that can be broken down with ultrasound can improve the safety of embolization therapy for cancer.

Wireless Wearable Blood Flow Sensor

Developing a wireless, wearable blood flow sensor will help alert hemodialysis patient caretakers about developing clogs.

Startling Speech: Eliciting Prepared Speech Using Startling Auditory Stimulus in Stroke Survivors

Measuring the facial muscles of stroke patients during startled speech can lead to improved speech therapy tools.

Studying Osteogenesis and Mineralization within Hyperglycemic In Vitro Cell Culture Models

Better understanding the complications of type 2 diabetes will ultimately improve upon current therapies.

The Effect of Visual Anticipation of Changes in Floor Compliance in Human Gait

Using virtual reality to see how humans anticipate changes in ground surfaces will help build better prosthetics and bipedal robots.

The Large Scale Expansion and Differentiation of Human Induced Pluripotent Stem-Cell Derived Neural Progenitor Cells

Developing a method to turn stem cells into neurons in large quantities can help with the study of Alzheimer’s disease.

The mathematical modeling of the dynamic migration of MDA-MB-231 cells within co-culture as well as in the presence of antifibrotic drug Tranilast and chemotherapy drug Doxorubicin utilizing a novel micro-engineered in vitro model.

Understanding the way cancer works at a cellular level would help make safer, more effective cancer treatments.

Smart Bike Human-in-the-Loop Control

Creating a smart bicycle that is able to maintain balance and control will help make riding a bike possible for people will disabilities.

Soft Robotic Foot Orthosis

Developing a soft robotic foot orthosis could lead to faster rehabilitation for foot injuries and eventually a squishy Iron Man suit.

Simple, Lumped Parameter Model to Simulate Blood Flow Through Bifurcations in the Human Cardiovascular System

Simulating blood flow through branched blood vessels could help diagnose and treat cardiovascular diseases.

Simulating Walking on Surfaces of Different Compliance using the ASU Variable Stiffness Treadmill

Simulating outdoor terrains with virtual reality and a treadmill can improve the versatility and performance of leg prosthetics.

Progerin-Induced Aging to Develop a Human-Induced Pluripotent Stem Cell Model of Alzheimer’s Disease

Studying the aging mechanism of pluripotent stem cells will help better model age-related Alzheimer’s disease.

Piloerection Sensor: Insight into Autonomic Function

Detecting and quantifying goosebumps allows for a new method of reliably detecting changes in emotion and the autonomic nervous system.

Preliminary Steps to a Micropipette-based Automated Patch Clamping System

Improving algorithms for an automated method of recording neuron activity will more efficiently locate and target cells of interest.

Rendering of Patterns on Social Mirror for Individuals who are Blind

Creating facial expression with vibration patterns will assist people who are blind in detecting nonverbal cues in conversations.

Photoacoustic Flowmetry

Developing a new method to locate circulating tumor cells in blood will lead to better prognosis information for ovarian cancer.

Optimizing recombinant protein production for domain antibodies: proof-of-concept

Creating a new production pipeline for nanoparticle therapeutics can improve treatment for traumatic brain injuries.

Opening Chromatin and Improving CRISPR/Cas9 editing with Engineered Pioneer Factors

Improving efficiency of genetic engineering techniques will reduce the trial and error costs of cell engineering.

Modification of Quorum Sensing Regulatory Systems in Pseudomonas Aeruginosa

Studying the genetic changes of a bacterial pathogen that affects cystic fibrosis patients will help develop less invasive diagnostic procedures.

IoT and Robotics in Pet Care

Designing a mobile robot that can encourage hunting behavior will help house cats get more exercise and avoid obesity.

Investigating Cancer Cell Death and Cell-Signaling Pathways using HSP90 Inhibition and APE1 Inhibition

Studying drug delivery to melanoma cells in 3D models will help understand melanoma survival pathways and provide new treatments.

How an Octopus Arm Can Outperform a Surgeon

Researching octopus-inspired soft robotics could advance robotic-assisted, minimally invasive surgery.

Inducible GFP Expression in Engineered Quorum Sensing Systems

Understanding promoters of gene regulation in response to cell population density will help advance bioengineering and synthetic biology.

Generation of an Inducible CRISPR/dCas9-KRAB System to Modulate Gene Expression

Using CRISPR to age model neurons for Alzheimer’s disease study will lead to better understanding and treatments.

Electrospinning Nanoscaffolds to Serve as Implants to Induce Tissue Regeneration in Patients

Fabricating and analyzing tunable nanoscaffolds could lead to implants that induce tissue regeneration.

Effects of Spatially and Temporally Manipulated Bioactive Signals on hMSC Behavior on NorHA Hydrogels

Evaluating bone cell behavior on particular hydrogels will lead to better understanding of gene expression.

Development of a guide robot to assist the blind with mobility and environmental awareness.

Developing a guide robot will allow increased physical activity and independence for people with visual impairments.

Design of a Portable Pneumatic System for Wearable Healthcare Assistive Devices

Studying dynamic behaviors of pneumatic systems will make the development of a wearable, soft-actuated, robotic knee sleeve possible.

Characterization of Ovarian Organoid with Gas Chromatography-Mass Spectrometry

Creating a controllable environment to monitor live cell development can lead to improved early stage disease screening.

Comparing Protocols for Extracting, Amplifying, and Imaging ApoE ε4 Allele: Preliminary work for understanding Alzheimer’s Disease in asymptomatic individuals

Imaging an allele known as a genetic risk factor for Alzheimer’s disease will help diagnose asymptomatic individuals.

All in the Hips: Exoskeletal Design for Rehabilitation and Lift-Support

Developing a backpack-style harness system to help workers lift things can prevent lifelong back and hip pain.

Active Temperature Managment for Transtibial Prosthetic Sockets

Active temperature management inside prosthetic sockets will reduce discomfort for people using lower leg prosthetics.

An Affordable Solution to EMG Prosthetics

Using 3D printing, functional hand prosthetics will be much more affordable.

Assistive Walking Device for Gait Disorder Patients

Creating an actively assisting wearable device will help people with gait disorders walk without dragging their feet.

3D Printing for Spatiotemporal Control of Stem Cell Behavior

3D-printing scaffolds of cross-linked hydrogels and live cells will enable a better way to study stem cells for orthopedic applications.

A Comprehensive Study of Sex Difference in Neuromuscular Control of the Knee Joint

Quantifying reasons behind ACL injuries based on sex will increase understanding help develop better rehabilitation methods.

A combined optical and electrical probe for electrophysiology

Developing new tools to study how neurons “talk” to each other will lead to a better understanding of the brain.

a Blood Based Diagnostic Approach for Rapid Diagnosis and Treatment Monitoring of Tuberculosis

Developing a blood-based tuberculosis diagnostic approach will result in rapid diagnosis and treatment monitoring.

Design of E-Textile Based EMG Sensors for Locomotion Analysis

Developing soft robotic orthotic devices would make rehabilitative devices more affordable and human-centric.

Creating a soft robotic knee brace can reduce pain and injury risk in laborers tasked with repetitive lifting

Creating a soft robotic knee brace can reduce pain and injury risk in laborers tasked with repetitive lifting.

Development of a Prosthetic Foot using Dielectric Elastomer Actuators

Studying the capabilities of electrically powered rubber can lead to a better prosthetic foot.

Diffusion of Dextran Across a Microfluidic Device Used to Model Native Myocardium

Building a better model of heart tissue damage from heart attacks can help develop better treatment methods.

Developing a treadmill-based exosuit will provide hospitals an affordable gait rehabilitation treatment for stroke patients.

Design and development of an oxygen-sensitive coating on carbon microelectrode to quantitatively assess pO2 changes around interface using novel siloxane-based MR imaging technique

Creating a novel technology to listen to neurons will help in monitoring the evolution of brain diseases and treatment efficiency.

Side-Viewing Photoacoustic and Ultrasound Imaging Probe

Designing a smaller diameter endoscopy probe may facilitate minimally invasive 360-degree imaging in the human body.

Comparative Assessment of DARPin and scFv for Neurodegenerative Disease Diagnostics

Beta-amyloid aggregation is one of the hallmark characteristics of Alzheimer’s disease. A4 is one of many scFv antibody fragments that the Sierks Lab has synthesized to bind to beta-amyloid with

Stochastic Modeling and Optimization to Improve Identification and Treatment of Alzheimer’s Disease

Alzheimer’s Disease (AD) is the 6th leading cause of death in the United States and affects more than 5 million people. AD can be detected at an early stage through

Adaptation of Laser Activated Sutures for Intestinal Surgeries via Chemical Cross-linking

This project seeks to adapt previously developed laser-activated sutures for use in intestinal surgeries. Previous work in this area developed laser activated sutures that improve wound healing by providing an

Photoacoustic Flow Cytometry

The objective of this research is to detect the presence of circulating tumor cells (CTCs) in a custom designed flow system. Determining the location of CTCs is crucial, as they

Evaluating the Effects of a Negatively-Damped Ankle-Foot Orthosis on Gait

The purpose of this research is to investigate the viability of negative damping as a control scheme for a wearable ankle exoskeleton. Negative damping can be thought of as the

Development of an Independent Compact Air Compression System for Soft Robotic Actuation

The purpose of this research is to develop a compact self-contained air compressor unit for use on-body with any pneumatically driven system. This device will allow future and current soft

Developing Novel 3D Printed Hydrogel-based Bioinks

The research team is developing a novel 3D printed hydrogel-based bioinks aimed at improving the understanding of and replicating the biochemical and biophysical cues required for musculoskeletal tissue function and

Potential Effect of Prolonged Weathering on Heavy Metal Leaching from Heavy-Metal-Treated-Wood

The research goal is to determine the effects of prolonged weathering of discarded heavy-metal-treated wood on heavy metal leaching. Seven heavy-metal-treated sample sets have been collected and prepared according to

Measuring Failure Load of Lumbar Spinous Processes to Transverse Mechanical Forces

This study will examine the yield strength of the lumbar spinous processes to mechanical forces applied in a transverse direction. Such forces will be generated clinically by neurosurgeons using a

Virtual Reality (VR) for Rehabilitation Therapy of Stroke Parkinson’s Disease and Athlete Patients

The objective of this research project is to collect and display data through a virtual reality experience that will help patients and general users determine if they are walking correctly

Effect of Cancer-Associated Fibroblasts on Breast Cancer Cell Migration Parameters

The research objective of this work is to study breast cancer cells’ migratory parameter, speed and persistence, in the presence of a stromal component, Cancer-Associated Fibroblasts (CAFs). To achieve this,

Stability of Ankle Motion in Eversion and Inversion Motion

This research project investigates the stability of the ankle in inversion and eversion using variable negative damping coefficients: -0.3, 0, 0.3. The angle of motion is tested by making a

Thermal Conductivity of Crystalline Polypyrrole

The purpose of this project is to investigate the thermal conductivity of crystalline polypyrrole (PPy) along its three-crystal directions. LAMMPS, a molecular dynamics simulator, was used to simulate PPy in

The Response of the Human Ankle to Variable Negative Damping

The development of wearable robots has the potential to drastically improve human lives. This study focuses on using a wearable ankle robot to quantify lower-limb motor control. After creating a

Modeling the Voluntary Reflex of the Human Ankle

This research provides a system model for the torque generation of a healthy human ankle undergoing voluntary reflex. This project also provides a physical platform to further study the ankle

Soft Robotic Control System

Traditional robotics employ rigid bodies to solve mechanical movement problems. Soft robotics are a class of robots that employ biomimicry to emulate the way natural systems produce movement and force.

Korwave: Wearable, Seizure Detection Headband

Korwave is a wearable, seizure detecting brain monitor for children with Epilepsy. Utilizing Bayesian machine learning techniques and a novel dry electrode, Korwave is a scalp EEG (Electroencephalogram) that is

Nanoparticle Delivery through a Resection-Disrupted Blood Brain Barrier for the Treatment of Glioblastoma

The standard of care for Glioblastoma (GBM) is surgical resection however, tumors reoccur within a few centimeters from the resection cavity behind an intact blood-brain-barrier (BBB). This project examined the

Evaluating the Effect of Visual Stimuli on the Intelligibility of Dysarthric Speech

The main goal of this project is to see if dysarthric speech can be more easily understood if a visual modality is introduced. Dysarthria is a speech disorder that makes

Wearable Sensor System to Aid in Ankle Rehabilitation

Of all the joints on the body, the ankle is the most susceptible to abuse which greatly impairs mobility. The development of a system of wireless sensors can aid in

Side-Viewing Photoacoustic and Ultrasound Imaging Probe

The objective of this research is to develop a side viewing photoacoustic (PA) and ultrasound (US) imaging probe for biomedical applications. Utilizing borosilicate glass capillary tubes as both optical and

Perception of Emotions Based on Tactile Facial Action Units by Individuals Who are Blind

There are a plethora of emotions that can be perceived through non-verbal communication cues, such as happiness, sadness, and anger. This puts blind and visually impaired individuals at a major

Analyzing Gait Perturbations to Assess Variability in Dynamic Stability for Fall Risk Assessment

This project seeks to investigate the variability dynamic stability measurements during gait velocity perturbation for fall risk assessment. Much research has been done analyzing static stability, taken when standing still

Vagus Nerve Stimulation To Treat Oromotor Dysfunction in a Rat Model of Parkinson’s Disease

More than 10 million people worldwide live with Parkinson’s disease (PD), which is caused by a lack of dopaminergic cells. While limb motor function is most commonly associated with PD,

Chemical Gradient Fabrication through Electrospinning

Musculoskeletal diseases plague the lives of 50 percent of people over the age of 18, costing Americans 45 billion dollars per year. This research aims to create a novel technique

Investigating Leg Prosthesis Kinematics for Walking on Surfaces of Different Compliance

This research is being conducted to investigate if leg kinematics are unique and can be characterized in reference to a 2-D plane when walking on surfaces of different compliance. By

Soft Robotics: A Quasi-Passive Knee Brace to Assist in Lifting

The goal of this research is to create a soft robotic knee brace in order to reduce the risk of injury, chronic pain, and osteoarthritis in laborers tasked with repetitive

Data Process Methods in the Design of Pressure Monitoring System for Scoliosis Fusion Surgery

Scoliosis fusion surgery is the common treatment for adolescent idiopathic scoliosis. However, a series of complications occur during the recovery time, which are often related to inaccurate implant positioning. The

All in the Hips: Exoskeletal Design for Occupational Lift-Support and Rehabilitation

The focus of this research is to design a wearable system that will augment the user’s own lifting capabilities. Occupational lifting puts significant strain on the hips and lower back

ASU Rise Lab’s Self Balancing Bicycle

The ASU RISE Lab’s autonomous bicycle project investigates the implementation of a self-driving bicycle for increased mobility and human-robot interaction research. This semester the research focus was on balance. Two

In Vitro Cell Culture Model on the Influence of Advanced Glycation End-Products and Type 2 Diabetes

Type 2 diabetes has been shown to be associated with an increased risk of osteoporotic fracture. During prolonged hyperglycemia present in diabetic microenvironments, glucose can react with proteins and/or lipids

Implementation of Self Adjustable Treadmill

Can you walk on a treadmill as comfortably as you would over ground? While this seems challenging, the implementation of a self-paced mode in the instrumented treadmill enables the treadmill

Sensor Efficacy in Measuring Bone Depth for Neurosurgical Applications

This project examines the efficacy of lumbar vertebral bone depth sensors for relevant surgical uses. This project attempts to categorize this by comparing multiple sensor types (ultrasound, resistance, and force)

Development of an Assistive Soft Robotic Device

The soft properties that give soft robotics its name make it an ideal choice for working with people. This project focuses on designing and evaluating soft robotics actuators in order

Point-of-Care Mutation Detection in Navajo Neurohepatopathy

Navajo neurohepatopathy (NNH) is a fatal genetic disorder often caused by 149G>A mutation in the MPV17 gene. NNH (affecting 1-in-1600 Navajo babies) is characterized by brain damage and liver disease/failure.

Haptic Vision Substitution

The Haptic Vision Substitution Project involves a device that will assist the blind in “feeling” their surroundings. The device that is under research and development consists of a palm-sized vibrating

Progerin-Induced Aging to Develop a Human-Induced Pluripotent Stem Cell Model of Alzheimer’s Disease

Alzheimer’s Disease (AD) has the sixth highest mortality rate in the United States with no known cure or treatment. To model late-onset disorders, such as AD, age-related phenotypes must be

A Higher-Quality Haptic Display

Professor Sodemann’s research team has been developing an improved haptic display for the visually impaired user to mentally visualize the environment in a more identifiable manner. A haptic display is

The Development of a Multi-Marker Sensor for Patients with Diabetes Mellitus

The research objective was to determine if electrochemical impedance spectroscopy (EIS) could be used to detect glucose and insulin simultaneously on a screen-printed carbon test strip. The glucose point-of-care (POC)

Assessing the Ability of Startle to Predict Learning Retention

The ability to learn and retain new motor tasks is essential to everyday life; however, the neural mechanisms governing this process are poorly understood to date. Recent evidence demonstrates that

Human Neural Progenitor Cell Transplantation Sustainment and Maturation with Immunodeficient Mice

This project addresses the feasibility of human neural progenitor cell (hNPC) transplantation into the striatum of immunodeficient mice. Injections of hNPCs and hNPCs encapsulated in a hyaluronic acid-laminin based hydrogel

Energy-Free Personal Security Wristband

The project aims to solve the shortage of current emergency calls through mobile devices. The stretchable wristband is designed to enhance the efficiency of responding to the emergency. GPS location

Chat-Box as Mood Analyzer for Individuals with Social Interaction Disabilities

More than 360 million people worldwide suffer from hearing impairments and autism. They also have a difficult time observing the social world and interpreting it. Similarly, the inherently ambiguous nature

Diagnostic Methods for Detecting Microvillus Inclusion Disease

Microvillus Inclusion disease is a life-threatening disease caused by a single nucleotide polymorphism (SNP) that affects people of Navajo descent. This research sought to design a diagnostic method with future

Integrated Sensing for a Soft Neuroprosthetic

Neuroprosthetic devices have unique design requirements, more so for bionic limbs that must operate in highly demanding work environments. The project explores synthetically recreating postural synergy using soft materials, artificial

Clinical Imaging Post-Processing to Improve Surgery in Focal Cortical Dysplasia Cases

Focal cortical dysplasia (FCD) is a brain malformation that commonly causes seizures and can be removed in epilepsy surgery. Automated techniques were implemented to detect FCD within a clinical MRI

Design of Compact Lower Limb Exoskeleton for Gait Assistance

Robotic Exoskeletons assist patients with impaired mobility due to aging and spinal cord injuries, which is becoming increasingly more prevalent. However, the present exoskeletons are either bulky or do not

Quantifying Post- Surgical Brain Shift to Improve Multi- Modal Imaging Application in Surgical Treatment of Epilepsy

The brain shifts following the implantation of intracranial electrodes used to monitor and map brain activity prior to epilepsy resection surgery. Evaluating the factors that contribute to the shift will

Mechanical Characterization of 3D Porous Electrospun Nanoscaffolds to Optimize Tissue Regenerative Response

Bioengineering the cell microenvironment is critical when developing cell-based therapeutic devices for regenerative medicine. The focus of this project is to characterize the micromechanical properties of 3D porous electrospun nanoscaffolds

Developing Prosthesis for Children with Disabilities to Participate in Sports

The main goal of the proposed project is to develop a comprehensive guide that summarizes the best materials to use for a prosthetic designed to facilitate specific sport-dependent gestures. To

Cortical Contributions of Sensory Gaiting to Voluntary Movement: A Somatosensory Evoked Potential Study

The research objectives are (1) to identify the changes of Somatosensory Evoked Potentials (SEP) amplitude during voluntary movements underlying sensorimotor integration by using Electroencephalography (EEG), and (2) quantify the correlation

Managing Respiratory Disease with Wearable Devices

Dust particles and ozone worsen symptoms in patients with respiratory disease. Currently only a single value is available for each pollutant representing the entire greater Phoenix area. The project goal

The Effects of Electrotactile Stimulation over Multiple Feedback Sites through Proprioceptive Mapping

Previous studies have shown that visual and somatosensory signals are required to estimate a user’s hand spatial locations in perspective to an area. Electrotactile stimulation can restore missing sensory responses

Elucidation of Stromal Fibroblast and Antifibrotic Drug on Chemo Resistance Within a 3D Model

The project objective was to study the effects of antifibrotic drugs on extracellular matrix (ECM) stiffness modulation and the related efficacy of various chemotherapy drugs. This was tested using a

Generation of an Inducible CRISPR/dCas9-KRAB System to Modulate Gene Expression

Current in-vitro Alzheimer’s disease models fail to recapitulate the critical risk factor of age because they yield immature neuronal populations that exhibit gene expression more closely resembling that of fetal

Design and Implementation of an Internet-of-Things (IoT) Based Activity Tracker for Pet Care

Having a sick pet can be stressful for the pet and owner. With Internet-of-things (IoT) technology, it can give the owner ease of mind. This research aims at developing an

Development of Multi-Sensor Intelligent Embedded System to Assist the Blind with Mobility & Environmental Awareness

The primary objective of this research is to build a low-cost multi-sensor embedded system that uses readily available components and that is sufficiently flexible to permit the development and demonstration

Acetone: A Promising Biomarker for Human Fat Metabolism

This research study focuses on the development of a wearable sensor for acetone quantification in skin headspace through measuring color change in a hydroxylamine coated substrate. The development of such

Training Deep Neural Networks with Quantization and Structured Sparsity

Deep learning algorithms have shown tremendous success in applications ranging from self-driving cars to medical diagnosis. However, their usage on embedded platforms, such as mobile devices, has been limited due

Development of a Conductive Injectable Hydrogel for Cardiac Tissue Engineering.

Cardiac damage caused by myocardial infarction is irreversible due to the limited regenerative capability of cardiomyocytes. Thus, treatment is challenging. Injectable hydrogels that can accommodate cardiac cells and allow tissue

MYO Integrated Hand Prosthesis

Functional prosthetics cost anywhere from $20,000 to $100,000 USD, making it difficult for many amputees around the globe to obtain the help they need to perform everyday tasks. The MYO-Integrated

Cervical Cancer Detector

The objective of this project is to develop a cervical cancer detector using wrinkle pattern recognition and pattern recognition technology. The device can analyze cell samples with high accuracy by

Large Scale Expansion and Differentiation of Pluripotent Stem Cell-Derived Neural Progenitor Cells from Amyotrophic Lateral Sclerosis Patients

Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease that currently presents a significant therapeutic challenge. Human pluripotent stem cell (hPSC) derived neural progenitor cells (hNPCs) offer a potential solution.

The Effects of Advanced Glycation End-Products and Type 2 Diabetes on Bone Regeneration

The goal of the study is to investigate the effects of advanced glycation end-products (AGEs) on human mesenchymal stem cells (hMSCs). Currently, a process to create AGEs has been determined

Aminoglycoside Polymers in Combination Treatments for Triple Negative Breast Cancer (TNBC) Studies

Each year in Arizona, breast cancer causes two deaths and more than 4,600 diagnosed cases. Triple-negative breast cancer is diagnosed in 30% of breast cancer cases. This research involves the

Evaluation of a Soft-Robotic Knee Exosuit for Stair ascent

This research evaluates a soft robotic exosuit worn around the knee joint to assist in ascending stairs for post-stroke and ACL reconstruction rehabilitation. The project goal is to compensate for

Active Temperature Managment for Transtibial Prosthetic Sockets

Transtibial amputations are rapidly increasing due to dysvascular complications associated with diabetes and 53% of amputees experience heat discomfort with their current prosthetic. Active temperature management with thermally conductive metals

A Deep Learning Autoencoder for EMG Changepoint Recognition in Robotic Applications

Electromyography (EMG) sensors can be added to a variety of devices for detecting nerve signals in muscles, but there is a need for better signal analysis techniques and more flexible

The Effect of Vibrotactile Stimulation on Upper Limb Proprioceptive Map Characteristics

The research makes definitive conclusions on how vibrotactile stimulation to the forefinger affects proprioceptive map error magnitude and direction. The data exhibits significant indications that vibrotactile stimulation to the forefinger

Design and Development of a Safe and Effective Upper Gastrointestinal Foreign Body Extraction Device

Current limitations in gastrointestinal foreign body extraction devices cause the removal of esophageal food impactions to take 30-90 minutes and involve upwards of nine devices. The product development team is

Norepinephrine and Adenosine Infused Microparticles for Brown Adipose Tissue Stimulation

The objective for this semester is to develop and optimize a protocol that consistently fabricates biodegradable microparticles of the correct dimensions, surface morphology, and narrows size distribution via fluid dynamics.

Modeling Extra Cellular Matrix (ECM) Re-organization Due to Cell-ECM Mechanical Interactions

This research focused on the systematic investigation of cell-ECM mechanical interactions through quantitative examination of 165 high-resolution time-lapse data of multi-cellular systems of collective cell migration. The researcher then focused

Bioresponsive Copolymers of Poly(N-isopropylacrylamide) with Enzyme-Dependent Lower Critical Solution Temperatures

Enzyme-degradable hydrogels are desirable for drug delivery and tissue engineering applications because they mimic biological systems. The aim of the project was to synthesize and characterize injectable, bioresponsive and bioresorbable

Development and Analysis of Reward-Adaptive Reinforcement Learning Agents

This research is attempting to develop an artificially intelligent reinforcement learning agent that can adapt to changes in its reward structure without performing training again. An agent has been developed

Electrocatalytic and Optical Properties of Various Hydrogen-Production Catalysts Immobilized at a Polymer-nanoITO Interface

Human-engineered systems capable of converting sunlight and water to fuels offer a promising approach to a sustainable energy future. One strategy includes coupling light-capture components with molecular catalysts, capable of

Parallel Exo-Skeletal Vehicle

Exoskeletons allow the user to carry more, move more efficiently, and reduce metabolic costs of such activities. However, the Exoskeleton itself must be carried by the strength of the user,

Soft Robotic Mobility Device

The purpose of this research is to develop an air pumping device that improves the mobility and effectiveness of a soft robotic medical device. This research was done by optimizing

Blood Based Mass Spectrometry Assay for Rapid Diagnosis and Treatment Monitoring of Tuberculosis

Tuberculosis (TB) remains a threat to millions of people, partly due to poor sputum-based diagnostic techniques which poses detection limitations to susceptible victims, such as pediatrics, Extrapulmonary TB, and HIV

Application of Axiomatic Distance Calculation of Incomplete Rankings in Genomics

The purpose of this project is to gain valuable insights about causal relationships between different sets of genes and diseases by designing ranking aggregation methods. The lack of comprehensive data

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