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Investigating the Role of SP5 in WNT Signaling Using an In-Vitro Model of Neural Patterning

This project attempts to better understand how the WNT transcriptional program is affected by β-catenin and SP5 by developing an in vitro model of neural patterning. This signaling pathway uses molecules that mediate cell to cell communication, which controls fundamental embryonic processes and regulates the formation of developmental markers. In the absence of WNT, the

Collecting Data for Pressure Ulcer Monitoring and Prevention System

In 2014, pressure ulcers affected approximately 2.5 million people in the United States. These blisters form in bony prominences in bed-bound patients. If untreated, these ulcers worsen until they become infected with complications. Current devices to prevent pressure ulcers fail to individualize patient treatment. The research team thus proposes the Pressure Ulcer Monitoring and Prevention

Risk Assessment and Terrestrial Plant Toxicity of Remediated Heavy Hydrocarbon Impacted Soil

The objective of the research was to determine the short-term ecological toxicity of ozonation byproducts on seed germination and on the mutagenic properties of bacteria. By helping define the eco-toxicity of ozonation techniques, this research will be used when considering the feasibility of field deployment of the previously established ozone techniques. Future research will focus

Pressure Ulcer Monitoring and Prevention System Algorithm

Machine learning algorithms used in biomedical applications indicate the ability of a medical device to make decisions similar to a physician. For this research, the researcher aims to address the issue of monitoring pressure ulcers which has lead to 60,000 deaths annually in the United States using machine learning. The algorithm that is being developed

Design and Characterization of Programmable FRET Biosensors

Fluorescence Resonance Energy Transfer (FRET) is a physical phenomenon that is being used in biomedical research and drug discovery. Using fluorophore-labeled DNA nanostructures, researchers characterize the FRET efficiency of a donor-acceptor pair. The result of this project is a measurement of FRET efficiency in the dye pair, JF 549 and Atto 647N, at 3-15 nm