Gabrielle Wipper

Biomedical engineering

Hometown: Germantown, Tennessee, United States

Graduation date: Spring 2020

Gabrielle Wipper
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FURI | Spring 2020

Discovering Factors That Drive the Migration of Immune Cells Into Malignant Pleural Mesothelioma Tumors

The goal of this research was to map the network of interactions influencing immune cell migration. A series of filters were applied to a transcriptional regulatory network to prioritize a list of chemokines, cytokines, and immunomodulatory genes associated with increased infiltration of immune cells related to patient survival. The chemokine IL-18 was identified as a factor influencing natural killer cell infiltration into malignant pleural mesothelioma (MPM). Currently experimentally determining if patient-derived MPM cell lines express IL-18, and developing a Boyden chamber assay to determine if IL-18 induces chemotaxis and tissue invasion.

Mentor:

Additional projects from this student

Studying biological factors that drive immune cell migration to glioblastoma tumor cells will increase understanding of cancer mechanisms.

Mentor:

  • FURI
  • Fall 2019

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