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Engineering  |  FURI

Gabrielle Wipper

Hometown: Germantown, Tennessee, United States | Graduation Date: Spring 2020
Biomedical engineering

Discovering Factors That Drive the Migration of Immune Cells Into Malignant Pleural Mesothelioma Tumors

Research Theme: Health
FURI: Spring 2020

The goal of this research was to map the network of interactions influencing immune cell migration. A series of filters were applied to a transcriptional regulatory network to prioritize a list of chemokines, cytokines, and immunomodulatory genes associated with increased infiltration of immune cells related to patient survival. The chemokine IL-18 was identified as a factor influencing natural killer cell infiltration into malignant pleural mesothelioma (MPM). Currently experimentally determining if patient-derived MPM cell lines express IL-18, and developing a Boyden chamber assay to determine if IL-18 induces chemotaxis and tissue invasion.

Other Projects

Discovering Factors that Drive the Recruitment of Macrophages to Glioblastoma Multiforme Tumor Cells

Research Theme: Health
FURI: Fall 2019

Currently, the researcher is working to produce a list of biological factors that may drive immune cell migration to Glioblastoma tumor cells. Discovering these factors may lead to improved quality of treatment options for patients. A survival analysis was conducted using available patient data. The researcher also ran statistical tests for mutations versus immune cells from the same data set. Computation is being done with available Mesothelioma data to find relative pathways between mutation, regulator, biclusters, and immune cells. Results will be replicated with Glioblastoma and be applied to highlighted biclusters to identify possible genetic targets to perturb during experimentation.

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