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Engineering  |  FURI

Amanda Marie Tran

Hometown: Arvada, Colorado, United States | Graduation Date: Spring 2021
Chemical engineering

Bioengineered Space-Like Protein Crystals on Earth: Implications to Regenerative Medicine

Research Theme: Health
FURI: Spring 2020

Regenerative medicine (RM) shows the possibility to regenerate 3D tissue and organs from cells given an appropriate extracellular microenvironment. A better understanding of the structure-function relationship between cell surface proteins, known as integrins, and the families of collagens, proteoglycans, and glycoproteins that make up the extracellular matrix (ECM) is crucial in developing RM. Crystallization of complex proteins is the limiting factor to their characterization by x-ray diffraction but recent studies show improved protein crystals grown in microgravity. The use of a ground-based, microgravity protein crystallization unit operation has application to RM on Earth and in space.

Other Projects

Development of Biomanufacturing Unit Operations for Human Cell Therapy (HCL) Good Manufacturing Practices (cGMP)

Research Theme: Health
FURI: Fall 2019

Regenerative medicine (RM) is an emerging technology being developed by scientists, engineers, and clinical specialists to revolutionize medicine. As humans lose tissues and organs due to injury or disease, it is now possible to regenerate 3D tissue from their own cells. Thus, RM offers personalized therapy, which is expected to improve the overall quality of life. However, government regulations, treatment costs, and operative inefficiencies prevent RM development. For RM to realize its full potential, specialized manufacturing tools, processes, and a skilled workforce are required. Key biomanufacturing bio-unit operations include 3D bioprinting, electrospinning, and custom bioreactors.

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