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Engineering  |  FURI

Jordan Cecile Todd

Hometown: Glendale, AZ, United States | Graduation Date: Spring 2020
Biomedical engineering

Loperamide Encapsulated Nanoparticles for Evaluating Blood Brain Barrier Permeability Post-Experimental Traumatic Brain Injury

Research Theme: Health
MORE: Spring 2020

Due to traumatic brain injury (TBI) presenting with extensive treatment challenges, this study created nanoparticles to evaluate the pharmacokinetics/pharmacodynamics associated with drug delivery in a compromised blood-brain barrier. Loperamide encapsulated poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) nanoparticles were fabricated for the future assessment of blood-brain barrier permeability. The nanoparticles were produced using a microfluidic system, and optimized the parameters of flow rate, ratio of aqueous to organic solvents, and polymer and drug concentrations. These parameters were then validated through the metrics of size, polydispersity index, and encapsulation efficiency.

Other Projects

Modeling Carriers and Biological Specimen Utility of a Molecular Diagnostic Biosensor for Navajo Neurohepatopathy

Research Theme: Health
FURI: Spring 2019

Navajo Neurohepatopathy (NNH) is caused by a single nucleotide polymorphism (SNP) and is fatal to the 1 in 1,600 Navajo children affected. To confirm positive NNH diagnoses, clinicians need to collect genetic samples noninvasively from the child and the mother (who would be a carrier if the child has NNH). Therefore, this study aimed to validate the diagnostic for heterozygous carriers and various biological sample types. To do so, derivative fluorescence outputs from a quantitative, real-time polymerase chain reaction (qPCR) assay were assessed to minimize false positives and negatives for these respective groups.

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