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Casey Silva

Hometown: Tempe, Arizona | Graduation Date: Spring 2019
Biomedical Engineering

The mathematical modeling of the dynamic migration of MDA-MB-231 cells within co-culture as well as in the presence of antifibrotic drug Tranilast and chemotherapy drug Doxorubicin utilizing a novel micro-engineered in vitro model.

Mentor: Mehdi Nikkhah
FURI: Fall 2018

The objective of this project was to dynamically model the migration of MDA-MB-231 cells within co-culture group as well as in the presence of antifibrotic drug Tranilast and chemotherapy drug Doxorubicin, using Delaunay triangulation. The micro engineered devices have been manufactured using soft lithography techniques, and drastic differences have been observed with regards to tumor cell migration across the various experimental conditions. Future studies should be conducted to more accurately characterize the migration patterns of tumor cells using different analytical techniques, and further elucidate the migratory tendencies of tumor cells across different experimental conditions.

Other Projects

Elucidation of Stromal Fibroblast and Antifibrotic Drug on Chemo Resistance Within a 3D Model

Mentor: Mehdi Nikkhah
FURI: Spring 2018

The project objective was to study the effects of antifibrotic drugs on extracellular matrix (ECM) stiffness modulation and the related efficacy of various chemotherapy drugs. This was tested using a novel high-density tumor microarray model containing tumor cells and fibroblast cells in coculture. The necessary micro engineered devices for this project have been manufactured, and drastic changes in both ECM stiffness and drug efficacy have been observed as a result of this joint treatment. In the future, more in depth mechanistic studies should be conducted to better understand the drugs that have been utilized for this study.