Carlie L Rein

Biomedical engineering

Hometown: Hillsdale, New Jersey, United States

Graduation date: Spring 2021

Rein-Carlie
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FURI | Fall 2019

Metabolic Engineering of Corynebacterium glutamicum for the Conversion of Biomass Derived Aromatics to Chrysin

The objective of the research project is to recombine the genetic pathway to produce naringenin and pinocembrin in Corynebacterium glutamicum, flavonoids found in plants. To modify the pathway, genes coding for C4H, 4CL, CHS, and CHI enzymes are transformed into bacterium and expressed in a defined order to manipulate the chemical structures to produce the compound. Once the production of flavonoids is confirmed from glucose, it can be tested for production from lignin-derived aromatics. This produce has the potential to produce pharmaceuticals from renewable resources. The process in which this compound is being produced will also be a more sustainable method.

Mentor:

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Additional projects from this student

Recombining the genetic pathway in bacteria to produce a pharmaceutical from a renewable resource will reduce price and improve availability.

Mentor:

  • FURI
  • Spring 2019

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