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Engineering  |  FURI

Tanya Nanda

Hometown: Tempe, Arizona, United States | Graduation Date: Fall 2020
Biomedical engineering

Engineering an Encapsulated 3D Tumor Dormancy Model In Vivo Using NRAS-Mutant Melanoma Cells

Mentor:
Research Theme: Health
KEEN, MORE: Spring 2020

Two-dimensional entrapment of tumor cells to study dormancy has been studied before using ECM-induced, cell signaling-induced, biochemical-induced, etc. modes for cancers such as prostate, lung, colorectal, pancreatic, etc. in vitro, but not in vivo. Due to the lack of three-dimensional (3D) in vivo models for such studies, this project hypothesizes that a 3D tumor dormancy model can be formed using polymer-based encapsulation of melanoma and breast tumor cells. This model consists of tumor cells cultured on a novel hydrogel platform to form spheroids to induce dormancy and their physical confinement by encapsulation in amikabeads, followed by injection and treatment in vivo.

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