Michelle M. Mungaray

Biomedical engineering

Hometown: Mesa, Arizona, United States

Graduation date: Fall 2022

Michelle Mungaray
Health icon, disabled. A red heart with a cardiac rhythm running through it.

MORE | Spring 2022

Development of Biomimetic Nanoparticles for Highly Efficient CRISPR Delivery

Recent advances in genome engineering, namely Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 gene editing, have revolutionized biomedical research and hold promise for treating genetic disorders. However, inefficient delivery and potential off-target effects remain the major obstacles, limiting clinical applications of gene editing. The objective of this MORE project is to develop novel cell membrane-cloaked nanoparticles carrying CRISPR/Cas9 plasmids complexed with cationic polymers, such as polyethyleneimine, to achieve highly efficient and site-specific delivery of gene editing constructs. The findings obtained from this study would provide new insights into the development of targeted nanomedicine and CRISPR-based therapies.

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Additional projects from this student

The successful implementation of the CRISPR interference system will allow for the advancement of cardiovascular therapeutics.

Mentor:

  • FURI
  • Spring 2021

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