Lauren Nicole Lossner

Biomedical engineering

Hometown: Mesa, Arizona, United States

Graduation date: Spring 2021

Lauren Lossner
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FURI | Spring 2021

Interictal Spike Depolarization in the Neocortex: Relationship to Action Potential Inactivation

Evaluated how local voltage changes due to interictal spikes impact action potential firing using intracellular recordings and the Hodgkin-Huxley model. The Hodgkin-Huxley model showed inactivated action potentials being generated by large depolarizations. The Hodgkin-Huxley model confirmed the effect of large interictal spike depolarizations on action potential firing and inactivation. This supports the hypothesis that interictal spikes may contribute to idiopathic seizure disorder.

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