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Karolena Lein

Hometown: Goodyear, Arizona | Graduation Date: Spring 2020
Biomedical Engineering

Ultrasound Cleavable Polymers for Reversible Vascular Embolization

Mentor: Brent Vernon
FURI: Spring 2019

Embolization therapy uses either particles, metal coils, or balloons to reduce blood supply to a targeted area, starving cancerous tissues. This proposal focuses on creating a polymer that can change from a gelled to a liquid state under high-intensity focused ultrasound (HIFU). With this an embolism that has been mistakenly placed or dislodged can be dissolved safely. Currently, the polymer P(NIPAM-co-tba) shows promise as an ultrasound sensitive biomaterial. Future studies should be conducted to modify this polymer for use within the body

Other Projects

Ultrasound Cleavable Polymers for Reversible Vascular Embolization

Mentor: Brent Vernon
FURI: Fall 2018

The primary goal of this research is to synthesize a polymer that can be broken down by high intensity focused ultrasound (HIFU). This polymer aims to improve the efficacy of embolization therapy, in which a material is injected into a vessel to block blood flow. While this therapy is useful in starving cancerous cells it can be dangerous, with some blockades in the brain dislodging and causing strokes or blindness. Current work focuses on the polymer PPODA-QT and observing the reaction under HIFU. Future work will expand to other polymers.