Alyssa Kritz

Biomedical engineering

Hometown: Chicago, Illinois, United States

Graduation date: Spring 2022

Health icon, disabled. A red heart with a cardiac rhythm running through it.

FURI | Spring 2022

Chemotherapeutic Drug-Conjugated Microbead Technology for Selective Binding with Methylated and Unmethylated Small DNA in the Application of Disease Detection and Biomanufacturing

In a previous study, it was discovered that aminoglycoside-derived cationic polymer microbeads (also called Amikabeads) have significant binding affinity toward negatively charged plasmid DNA due to coulombic interactions. The purpose of this study is to develop a small library of modified Amikabeads with a variety of DNA-intercalating chemotherapeutic drug molecules to modulate the ability of DNA binding. Further investigation on how these ligand-modified beads interact with small methylated and unmethylated DNA fragments (which mimics circulating tumor DNA or ctDNA) would help to develop a new technology for cancer detection and aid in improving biomanufacturing methods in the future.

Mentor:

Additional projects from this student

Studying the interactions between chemotherapeutic drug-conjugated microbeads and small DNA fragments will help develop new biotechnology for cancer detection.

Mentor:

  • FURI
  • Fall 2021

FURI Totals

TotalStudents

0

FacultyMentors

0

OnlineSymposia

0

FocusAreas

0

FURIProjects

0

MOREProjects

0

KEENProjects

0

GCSPProjects

0