Shivani Chandrashekher Swamy Hiremath
Hometown: Bengaluru, Karnataka, India
Graduation date: Fall 2021
MORE | Fall 2021
Immunomodulatory Exosome Loaded Synthetic Hydrogels for Cell EncapsulationPregnancy is a natural phenomenon where tissue types of different antigen signatures co-exist without eliciting an immune response from the host. Immunomodulation occurs in a site-specific manner at this interface and trophoblast cells found in the placenta are believed to play a role. In order to understand and mimic this site-specific immunomodulation, trophoblast representative cell lines are brought under study, specifically, the extracellular vesicles released by them called exosomes. Following isolation and characterization of exosomes, they are encapsulated within hydrogels such as polyethylene glycol and alginate to monitor their release profile as well as their effects on immune cell lines.
Mentor: Jessica Weaver
Sponsored project | Fall 2021
W. L. Gore & Associates is a uniquely creative, product leadership enterprise that has served a variety of global markets for 60 years, and provides innovative solutions that its associates stand behind. Gore established funds to support undergraduate students in the Fulton Undergraduate Research Initiative program and graduate students in the Master’s Opportunity for Research in Engineering program, and values student-driven research and developing relationships with students in the programs.