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Shannon Grassi

Hometown: Gilbert, Arizona | Graduation Date: Spring 2019
Biomedical Engineering

Human Neural Progenitor Cell Transplantation Sustainment and Maturation with Immunodeficient Mice

Mentor: David Brafman, Sarah Stabenfeldt
FURI: Spring 2018

This project addresses the feasibility of human neural progenitor cell (hNPC) transplantation into the striatum of immunodeficient mice. Injections of hNPCs and hNPCs encapsulated in a hyaluronic acid-laminin based hydrogel (HA-Lm gel) were performed. Immunohistochemistry (IHC) was performed 7 and 14 days post-injection for key cell lineage specific markers. These markers will allow for quantitative analysis of the transplanted hNPCs and evaluate the maturation in the host brain. By determining the sustainment and fate of hNPCs into the mouse following transplantation, hNPC therapy for neural injury may be investigated.