Simone Breanna Gohsman

Biomedical engineering

Hometown: Mesa, Arizona, United States

Graduation date: Spring 2023

Additional details: First-generation college student

Simone Gohsman
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FURI | Spring 2022

Viability and Metabolic Function of INS-1E Cells in Synthetic PEG Hydrogels Suitable to Injection Molding Biofabrication

Pancreatic islet encapsulation has the potential to reverse Type 1 diabetes by protecting transplanted beta cells from immune-cell destruction while allowing passive diffusion of nutrients through a synthetic non-degradable hydrogel barrier. Strain promoted alkyne-azide cycloaddition (SPAAC) reactions, also called copper-free click chemistry, occur at biological pH and temperature, lack cytotoxic catalysts, and have tunable gelation speeds ranging from 1 to 15 minutes. This research tests the viability and metabolic function of INS-1E cells encapsulated in SPAAC-functionalized PEG hydrogels compared to thiol-maleimide hydrogels, as the slower gelation speed of SPAAC hydrogels are advantageous in generating complex encapsulation geometries that optimize cell viability.

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