Report an accessibility problem
Engineering  |  FURI

Glenna Bea Embrador

Hometown: Phoenix, Arizona | Graduation Date: Spring 2019
Biomedical Engineering

Optimizing Recombinant Protein Production for Domain Antibodies: Proof-of-Concept

Mentor: Sarah Stabenfeldt
FURI: Spring 2019

Recent studies in traumatic brain injury (TBI) have found a temporal window where nanometer scale therapeutics can cross the blood-brain barrier into the parenchyma. Development of recombinant antibody production is attractive due to its wide range of biological applications in diagnostic and therapeutic use. However, the production pipeline for high yield, purified, and consistent bioactive recombinant proteins remains a major obstacle. This project aims to optimize this methodology and evaluate the potential to use Brevibacillus host to produce biologically active domain antibody proteins for future use in nanoparticle therapeutics.

Other Projects

Optimizing recombinant protein production for domain antibodies: proof-of-concept

Mentor: Barbara Smith
FURI: Fall 2018

Recent studies in traumatic brain injury (TBI) have found a temporal window where therapeutics on the nanometer scale can cross the blood-brain barrier and enter the parenchyma. Developing protein-based therapeutics is attractive for a number of reasons, yet, the production pipeline for high yield and consistent bioactive recombinant proteins is a major obstacle. This project directly addresses this issue and evaluates the potential to use Brevibacillus host to produce biologically active domain antibody proteins for future use in nanoparticle therapeutics.