Maren C Eltze

Biomedical engineering

Hometown: Tucson, Arizona, United States

Graduation date: Spring 2021

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FURI | Summer 2020

Directed Evolution for Biological Sensors

Complex synthetic biology methods demand the integration of continuous culture, directed evolution, and positive/negative selection methods. To achieve this in a single platform, the research team built an open source multiplexed bioreactor (eVOLVER) and modified it to function as a directed evolution system. Modifications include a turbidostat, for continuous feed of bacteria into experiments, and a two-lagoon system, allowing for both positive and negative selection. The team has developed a theoretical system that is currently being implemented to create the physical system. Once established, this technology will be the basis for next generation biological sensors and bioactive proteins.

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