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Matthew Chrest

Hometown: Murrieta, California | Graduation Date: Spring 2019
Biomedical Engineering

Photoacoustic Flowmetry

Mentor: Barbara Smith
FURI: Fall 2018

Locating circulating tumor cells (CTCs) is crucial as they yield prognosis information for ovarian cancer. Current methods used to diagnose ovarian cancer include documenting CA-125 concentrations and transvaginal ultrasounds. It is difficult to find and differentiate between CTCs and other cells already circulating through blood. This study will discuss the use of photoacoustic flowmetry (PAF) to locate CTCs that have been coated with CuS nanoparticles circulating through a designed flow system. The hypothesis is that the CuS nanoparticles will bind to the CTCs using folic acid due to the folic acid receptors on CTCs.

Other Projects

Photoacoustic Flow Cytometry

Mentor: Barbara Smith
FURI: Spring 2018

The objective of this research is to detect the presence of circulating tumor cells (CTCs) in a custom designed flow system. Determining the location of CTCs is crucial, as they indicate the presence of cancer and can provide diagnostically relevant information, such as the stage of cancer development. It is difficult to detect CTCs in blood, so to aid in their detection, copper-sulfide nanoparticles are functionalized to bind specifically to ovarian cancer CTCs. The nanoparticles act as a photoacoustic contrast agent, allowing for the detection of CTCs through photoacoustic flowmetry (PAF) in a custom designed flow system.