Every year, myocardial infarction (MI) is responsible for over 25% of all global deaths and is expected to increase due to the oncoming obesity epidemic. Despite the unworldly lethality of this disease, along with the evermore increasing influence of MI, society is currently without a viable disease model that is apposite to human physiology; however, a three-Dimensional microfluidic device creates an admissible physiologically relevant environment. This project utilizes the device in order to optimize cardiac tissue viability, as well as measure molecular diffusion within the device and serves as the basis for future studies in myocardial infarction disease modeling.
Every year, 1.2 million people suffer from myocardial infarction in the United States, despite this extreme severity there is no disease model that is pertinent to that of the human physiology. However, a three-Dimensional (3D) microfluidic device creates an admissible physiological environment that is specialized for both, tissue observation and disease modeling. This project will utilize the microfluidic device to optimize cardiac tissue viability within different 3D hydrogels, as well as measure molecular diffusion across the hydrogel within the device. This project is the basis for future studies that employs this generated physiologically relevant environment to study myocardial infarction.