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Engineering  |  FURI

Omar Abed

Hometown: Maricopa, Arizona, United States | Graduation Date: Spring 2020
Chemical engineering

Engineering of High Yield Production of L-Serine in Cyanobacterium Synechococcus sp. PCC 7002

Research Theme: Sustainability
GCSP: Spring 2020

Cyanobacteria have the potential to efficiently produce L-serine, an industrially important amino acid, directly from CO2 and sunlight, which is a more sustainable and inexpensive source of energy as compared to current methods. The research aims to engineer a strain of cyanobacteria that increases L-serine production by mutating regulatory mechanisms that natively inhibit its production, encoding the optimal serine exporter, and removing genes responsible for its degradation. The work can be extended by tuning gene expression levels, optimizing growth conditions, and investigating the effects of nitrogen supplementation for the strain.

Other Projects

Engineering High Yield Production of L-Serine in Cyanobacteria

Research Theme: Sustainability
FURI: Fall 2019

Cyanobacteria have the potential to efficiently produce L-serine, an industrially important amino acid, directly from CO2 and sunlight, which is a more sustainable and cheaper source of energy as compared to current methods. The research aims to maximize the production of L-serine in a metabolically engineered strain of cyanobacteria by optimizing the expression levels of the serA and serine exporter genes, optimizing the growth conditions, and investigating the effects of nitrogen supplementation. The L-serine levels will be tracked using gas chromatography. The work can be extended by the deletion of genes that are involved in the amino acid’s degradation.

Engineering of High Yield Production of L-Serine in Cyanobacteria

Research Theme: Sustainability
FURI: Spring 2019

Cyanobacteria have the potential to efficiently produce L-serine, an industrially important amino acid, directly from CO2 and sunlight, which is a more sustainable and cheaper source of energy as compared to current methods. The research aims to engineer a strain of cyanobacteria that increases L-serine production by mutating regulatory mechanisms that natively inhibit its production, overexpressing the needed bio-synthetic genes, and encoding a serine exporter. After the creation of the strain, L-serine levels will be tracked using liquid chromatography. The work can be extended by deletion of genes that are involved in the amino acid’s degradation.

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