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Engineering  |  FURI
FURI Spring 2018
Health

Progerin-Induced Aging to Develop a Human-Induced Pluripotent Stem Cell Model of Alzheimer’s Disease

Alzheimer’s Disease (AD) has the sixth highest mortality rate in the United States with no known cure or treatment. To model late-onset disorders, such as AD, age-related phenotypes must be reintroduced into the DNA of the cells. The accumulation of the progerin protein is associated with aging. Using in-vitro techniques, it is hypothesized that overexpressing progerin through the generation of a lentiviral system will artificially age human induced pluripotent stem cell (hiPSC) derived neurons to model AD. Age-related phenotypes in hiPSCs will be analyzed via immunofluorescence (IF) microscopy and mitochondrial superoxide assays to confirm the identity of the hiPSCs.

Portrait of Frisch, Carlyle

Carlye Frisch

Scottsdale, Arizona

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