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Progerin-Induced Aging to Develop a Human-Induced Pluripotent Stem Cell Model of Alzheimer’s Disease

More than 5 million people currently live with Alzheimer’s Disease (AD), with no major life-extending treatment or cure. Reprogramming human-induced pluripotent stem cells (hiPSCs) resets the age to a fetal stage. Age-related phenotypes must be reintroduced into the DNA of the cells. Accumulation of the progerin protein is seen to be associated with aging. Using in-vitro techniques, it is hypothesized that the overexpression of progerin through a lentiviral system will artificially age hiPSC derived neurons to model Alzheimer’s Disease. Age-related phenotypes will be analyzed via immunofluorescence (IF) microscopy and mitochondrial superoxide assays, confirming the identity of the hiPSCs.

Symposium Participant

Portrait of Frisch, Carlyle

Carlye Frisch

Project Details

Symposium Date: Fall 2018

Research Theme: Health

Presentation Type: FURI

Faculty Mentors

  • David Brafman