FURI | Spring 2020

Discovering Factors That Drive the Migration of Immune Cells Into Malignant Pleural Mesothelioma Tumors

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The goal of this research was to map the network of interactions influencing immune cell migration. A series of filters were applied to a transcriptional regulatory network to prioritize a list of chemokines, cytokines, and immunomodulatory genes associated with increased infiltration of immune cells related to patient survival. The chemokine IL-18 was identified as a factor influencing natural killer cell infiltration into malignant pleural mesothelioma (MPM). Currently experimentally determining if patient-derived MPM cell lines express IL-18, and developing a Boyden chamber assay to determine if IL-18 induces chemotaxis and tissue invasion.

Student researcher

Gabrielle Wipper

Gabrielle Wipper

Biomedical engineering

Hometown: Germantown, Tennessee, United States

Graduation date: Spring 2020

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