FURI | Summer 2020
Directed Evolution for Biological Sensors
Complex synthetic biology methods demand the integration of continuous culture, directed evolution, and positive/negative selection methods. To achieve this in a single platform, the research team built an open source multiplexed bioreactor (eVOLVER) and modified it to function as a directed evolution system. Modifications include a turbidostat, for continuous feed of bacteria into experiments, and a two-lagoon system, allowing for both positive and negative selection. The team has developed a theoretical system that is currently being implemented to create the physical system. Once established, this technology will be the basis for next generation biological sensors and bioactive proteins.
Maren C Eltze
Hometown: Tucson, Arizona, United States
Graduation date: Spring 2021