Neural interfaces and technologies for assessing partial pressure of oxygen (pO2) are critical for understanding brain function in vivo. Merging both technologies into a single device capable of long-term measurements is of interest for monitoring evolution of brain diseases and treatment efficiency. Yet, integration is challenging with existing technologies. The aim of this research was to design and develop a novel carbon-based microelectrode that measures pO2 through its soft polydimethylsiloxane (PDMSO) coating using PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels) imaging technique. Significant development of a batch fabrication was achieved, and long-term stability assessment is in progress.