Current optical imaging techniques have a limited penetration depth based on the high attenuation of visible light in biological tissue. Fluorescent and photoacoustic microscopy are methods currently used to explore in vivo tissue samples. However beneficial, these current techniques still lack penetration depth past 2 mm. By utilizing both fluorescence and photoacoustics, and by incorporating near-infrared (NIR) wavelengths, we are creating a multi-disciplinary microscopy platform where imaging at a greater depth can be achieved. Through this research, we aim to create value for neuroscientists by developing technology that will assist them in better understand neuronal interactions.