FURI | Spring 2022
Characterization of Trophoblast Derived Exosomes to Engineer an Immunomodulatory Macroencapsulation Device for Cell Therapies
Trophoblasts are cells that populate the human placenta and release extracellular vesicles called exosomes, involved in cell-to-cell communication. Trophoblasts are believed to be involved in site-specific immunomodulation and their exosomes may play a role in preventing immunological attack of the fetus despite presenting foreign antigens. Isolation of these exosomes and their encapsulation within hydrogel macroencapsulation matrices could allow for sustained localized immunomodulation with potential applications in cell therapies such as islet transplantation to treat Type 1 diabetes.
Alfonso Serrano Vicente
Hometown: Lorca, Murcia, Spain
Graduation date: Spring 2022