Senescent and quiescent cells are cells that stop proliferating due to a variety of factors, including stress-induced senescence. Recognizing these cells through MR imaging can help detect dormant cancer tumors. It has been shown that an enzyme called β-galactosidase (β-gal) is upregulated in senescent and quiescent cells.The combination of S-gal® and ferric ammonium citrate (FAC)
Finding a molecule that can identify dormant cancer cells will help develop better tumor characterization and treatment.
Creating a novel technology to listen to neurons will help in monitoring the evolution of brain diseases and treatment efficiency.
Focal cortical dysplasia (FCD) is a brain malformation that commonly causes seizures and can be removed in epilepsy surgery. Automated techniques were implemented to detect FCD within a clinical MRI that can guide surgical remediation. This project developed a post-processing pipeline of structural MRI (T1 and FLAIR) to quantify local cortical deformation and grey-white blurring
The brain shifts following the implantation of intracranial electrodes used to monitor and map brain activity prior to epilepsy resection surgery. Evaluating the factors that contribute to the shift will help improve interpretation of the data monitored. Specifically, the researchers evaluated the effect age and brain volume have on the amount of post-surgical brain shift.