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Comparative Assessment of DARPin and scFv for Neurodegenerative Disease Diagnostics

Beta-amyloid aggregation is one of the hallmark characteristics of Alzheimer’s disease. A4 is one of many scFv antibody fragments that the Sierks Lab has synthesized to bind to beta-amyloid with the goal of detecting and preventing misfolding. Sierks Lab has also developed DARPin and designed Ankyrin repeat proteins that perform the same function, such as