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Characterization of Human Myocardial Tissue Model on a Microfluidic Device

Myocardial infarction is the most prominent cause of heart failure in the U.S. affecting 5.8 million people yearly. Despite the increasing number of affected, there is a lack in understanding as to how the molecular cues involved in a heart attack are created and the specific interactions between the cells that create the formation of

Diffusion of Dextran Across a Microfluidic Device Used to Model Native Myocardium

Every year, myocardial infarction (MI) is responsible for over 25% of all global deaths and is expected to increase due to the oncoming obesity epidemic. Despite the unworldly lethality of this disease, along with the evermore increasing influence of MI, society is currently without a viable disease model that is apposite to human physiology; however,

Utilizing Human Induced Pluripotent Stem Cells Conjugated to Biocompatible Gold Nanorods to Enhance Synchronous Beating and Functional Characteristics Similar to in vivo Cardiac Tissue

Myocardial infarction (MI), also known as heart attack, is one of the main causes of death in the United States. Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) are a potential strategy for repairing damage from MI. Electrically conductive nanomaterials, such as graphene oxide and siNWs, have been promising with improving adhesion and functional

Effect of Cancer-Associated Fibroblasts on Breast Cancer Cell Migration Parameters

The research objective of this work is to study breast cancer cells’ migratory parameter, speed and persistence, in the presence of a stromal component, Cancer-Associated Fibroblasts (CAFs). To achieve this, a 3D micropatterned in vitro model recapitulating the native tumor environment has been utilized. Two major cell lines are being studied: the minimally invasive MCF-7

Elucidation of Stromal Fibroblast and Antifibrotic Drug on Chemo Resistance Within a 3D Model

The project objective was to study the effects of antifibrotic drugs on extracellular matrix (ECM) stiffness modulation and the related efficacy of various chemotherapy drugs. This was tested using a novel high-density tumor microarray model containing tumor cells and fibroblast cells in coculture. The necessary micro engineered devices for this project have been manufactured, and

Development of a Conductive Injectable Hydrogel for Cardiac Tissue Engineering.

Cardiac damage caused by myocardial infarction is irreversible due to the limited regenerative capability of cardiomyocytes. Thus, treatment is challenging. Injectable hydrogels that can accommodate cardiac cells and allow tissue formation could offer a promising strategy to repair damaged hearts. In this study, a conductive injectable hydrogel was created by incorporating gold nanowires (GNWs) into