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Investigating the Role of SP5 in WNT Signaling Using an In-Vitro Model of Neural Patterning

This project attempts to better understand how the WNT transcriptional program is affected by β-catenin and SP5 by developing an in vitro model of neural patterning. This signaling pathway uses molecules that mediate cell to cell communication, which controls fundamental embryonic processes and regulates the formation of developmental markers. In the absence of WNT, the

Applying Developmental Biology Principles to Probe the Mechanisms of Selective Cell Vulnerability in Alzheimer’s Disease Using Human Induced Pluripotent Stem Cells

Alzheimer’s Disease (AD) affects over 5 million individuals in the US. The idea behind selective cell vulnerability in AD and various amyloid-dependent have been postulated. However, such mechanistic studies do not consider all the aspects of the human disease. This research leverages the ability for the generation of neural cell types of various regional identities