Synthesizing a polymer that can be broken down with ultrasound can improve the safety of embolization therapy for cancer.
The objective for this semester is to develop and optimize a protocol that consistently fabricates biodegradable microparticles of the correct dimensions, surface morphology, and narrows size distribution via fluid dynamics. This objective is being completed via proof-of-principle experiments and a DOE study. The proof-of-principle experiments allow for the exploration and proof of concept while the
Enzyme-degradable hydrogels are desirable for drug delivery and tissue engineering applications because they mimic biological systems. The aim of the project was to synthesize and characterize injectable, bioresponsive and bioresorbable poly(NIPAAm)-based copolymers with enzyme-degradable side chains. These copolymers may be useful for applications such as enzyme-triggered drug delivery and bioresorbable scaffolds for tissue engineering. The