Electrical recordings of individual neurons deep within the brain are key to enhancing understanding of neuronal dynamics. Unfortunately, optical microscopy, which is used to visualize neurons during the recording process, is limited to penetration depths of 500 to 1000 μm due to the optical scattering properties of biological tissues. In this work, researchers use an
The photoacoustic effect occurs when a target absorbs a specific wavelength of light, resulting in thermal expansion and the production of subsequent pressure waves. This phenomenon can be used in a variety of biomedical applications with minimal impact on tissue samples. The objective of this work is to measure the photoacoustic effect from multiple cell
Improving algorithms for an automated method of recording neuron activity will more efficiently locate and target cells of interest.
Developing a new method to locate circulating tumor cells in blood will lead to better prognosis information for ovarian cancer.
Creating a new production pipeline for nanoparticle therapeutics can improve treatment for traumatic brain injuries.
Creating a controllable environment to monitor live cell development can lead to improved early stage disease screening.
Developing new tools to study how neurons “talk” to each other will lead to a better understanding of the brain.
Designing a smaller diameter endoscopy probe may facilitate minimally invasive 360-degree imaging in the human body.
The objective of this research is to detect the presence of circulating tumor cells (CTCs) in a custom designed flow system. Determining the location of CTCs is crucial, as they indicate the presence of cancer and can provide diagnostically relevant information, such as the stage of cancer development. It is difficult to detect CTCs in
The objective of this research is to develop a side viewing photoacoustic (PA) and ultrasound (US) imaging probe for biomedical applications. Utilizing borosilicate glass capillary tubes as both optical and acoustic waveguides allows for PA/US endoscopy probes with diameters much smaller than traditional PA/US endoscopy probes. This decrease in size of the PA/US endoscopy probe